ZBTB3
Zinc finger and BTB domain-containing protein 3
Also known as: FLJ23392, ZBTB3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H5J0
- Gene
- ZBTB3
- Ensembl
- ENSG00000185670
- Chromosome
- 11
- Canonical length
- 574 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Mitochondria
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
574 residues, UniProt reviewed canonical sequence.
>Q9H5J0|ZBTB3
1 MLREFSKWGV EASPGKAWER KRSLLRGAVG RYRGATGGDL FWAPFPSWGT MEFPEHSQQL
61 LQSLREQRSQ GFLCDCTVMV GSTQFLAHRA VLASCSPFFQ LFYKERELDK RDLVCIHNEI
121 VTAPAFGLLL DFMYAGQLTL RGDTPVEDVL AAASYLHMND IVKVCKRRLQ ARALAEADST
181 KKEEETNSQL PSLEFLSSTS RGTQPSLASA ETSGHWGKGE WKGSAAPSPT VRPPDEPPMS
241 SGADTTQPGM EVDAPHLRAP HPPVADVSLA SPSSSTETIP TNYFSSGISA VSLEPLPSLD
301 VGPESLRVVE PKDPGGPLQG FYPPASAPTS APAPVSAPVP SQAPAPAEAE LVQVKVEAIV
361 ISDEETDVSD EQPQGPERAF PSGGAVYGAQ PSQPEAFEDP GAAGLEEVGP SDHFLPTDPH
421 LPYHLLPGAG QYHRGLVTSP LPAPASLHEP LYLSSEYEAA PGSFGVFTED VPTCKTCGKT
481 FSCSYTLRRH ATVHTRERPY ECRYCLRSYT QSGDLYRHIR KAHNEDLAKR SKPDPEVGPL
541 LGVQPLPGSP TADRQSSSGG GPPKDFVLAP KTNILocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZBTB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 5.4 nTPM
Expression across tissuesHPA
Tissue
- skin: 5.4 nTPM
- stomach: 4.7 nTPM
- fallopian tube: 4 nTPM
- salivary gland: 3.2 nTPM
- tongue: 3 nTPM
- heart muscle: 2.8 nTPM
Single-cell type
- late spermatids: 18 nCPM
- early spermatids: 16 nCPM
- megakaryocytes: 12 nCPM
- medullary thymic epithelial cells: 12 nCPM
- oligodendrocytes: 9.1 nCPM
- retinal pigment epithelial cells: 8.5 nCPM
Immune cell
- eosinophil: 9.4 nTPM
- classical monocyte: 7.1 nTPM
- total PBMC: 6.2 nTPM
- T-reg: 5.9 nTPM
- intermediate monocyte: 5.6 nTPM
- myeloid DC: 5.2 nTPM
Brain region
- white matter: 22 nTPM
- basal ganglia: 15 nTPM
- medulla oblongata: 14 nTPM
- cerebral cortex: 14 nTPM
- pons: 14 nTPM
- midbrain: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.68
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 1.08
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZBTB3 as an antibody target. Whether an autoantibody or antibody against ZBTB3 could matter depends on whether native ZBTB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZBTB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZBTB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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