Seroatlas · Human Serome Atlas

KCNA7

Potassium voltage-gated channel subfamily A member 7

Also known as: HAK6, KCNA7_HUMAN, Kv1.7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96RP8
Gene
KCNA7
Ensembl
ENSG00000104848
Chromosome
19
Canonical length
456 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Voltage-gated ion channels
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

456 residues, UniProt reviewed canonical sequence.

>Q96RP8|KCNA7
     1  MEPRCPPPCG CCERLVLNVA GLRFETRART LGRFPDTLLG DPARRGRFYD DARREYFFDR
    61  HRPSFDAVLY YYQSGGRLRR PAHVPLDVFL EEVAFYGLGA AALARLREDE GCPVPPERPL
   121  PRRAFARQLW LLFEFPESSQ AARVLAVVSV LVILVSIVVF CLETLPDFRD DRDGTGLAAA
   181  AAAGPFPAPL NGSSQMPGNP PRLPFNDPFF VVETLCICWF SFELLVRLLV CPSKAIFFKN
   241  VMNLIDFVAI LPYFVALGTE LARQRGVGQQ AMSLAILRVI RLVRVFRIFK LSRHSKGLQI
   301  LGQTLRASMR ELGLLIFFLF IGVVLFSSAV YFAEVDRVDS HFTSIPESFW WAVVTMTTVG
   361  YGDMAPVTVG GKIVGSLCAI AGVLTISLPV PVIVSNFSYF YHRETEGEEA GMFSHVDMQP
   421  CGPLEGKANG GLVDGEVPEL PPPLWAPPGK HLVTEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 75 nTPM
  • tongue: 19 nTPM
  • heart muscle: 0.9 nTPM
  • esophagus: 0.6 nTPM
  • salivary gland: 0.4 nTPM
  • skin: 0.3 nTPM

Single-cell type

  • myonuclei: 22 nCPM
  • thymic myoid cells: 6.8 nCPM
  • oocytes: 4.6 nCPM
  • platelets: 2.8 nCPM
  • epicardial cells: 2.3 nCPM
  • cone photoreceptor cells: 2.1 nCPM

Immune cell

  • basophil: 0.8 nTPM
  • neutrophil: 0.4 nTPM
  • classical monocyte: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • white matter: 2.5 nTPM
  • cerebral cortex: 2.2 nTPM
  • medulla oblongata: 2 nTPM
  • pons: 2 nTPM
  • thalamus: 2 nTPM
  • cerebellum: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0.14
gnomAD missense Z
0.42
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNA7 as an antibody target. Whether an autoantibody or antibody against KCNA7 could matter depends on whether native KCNA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNA7 is annotated at the cell surface, where native KCNA7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNA7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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