Seroatlas · Human Serome Atlas

ZBTB34

Zinc finger and BTB domain-containing protein 34

Also known as: ZBT34_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCN2
Gene: ZBTB34
Canonical length: 500 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ZBTB34 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>Q8NCN2|ZBTB34
     1  MDSSSFIQFD VPEYSSTVLS QLNELRLQGK LCDIIVHIQG QPFRAHKAVL AASSPYFRDH
    61  SALSTMSGLS ISVIKNPNVF EQLLSFCYTG RMSLQLKDVV SFLTAASFLQ MQCVIDKCTQ
   121  ILESIHSKIS VGDVDSVTVG AEENPESRNG VKDSSFFANP VEISPPYCSQ GRQPTASSDL
   181  RMETTPSKAL RSRLQEEGHS DRGSSGSVSE YEIQIEGDHE QGDLLVRESQ ITEVKVKMEK
   241  SDRPSCSDSS SLGDDGYHTE MVDGEQVVAV NVGSYGSVLQ HAYSYSQAAS QPTNVSEAFG
   301  SLSNSSPSRS MLSCFRGGRA RQKRALSVHL HSDLQGLVQG SDSEAMMNNP GYESSPRERS
   361  ARGHWYPYNE RLICIYCGKS FNQKGSLDRH MRLHMGITPF VCKFCGKKYT RKDQLEYHIR
   421  GHTDDKPFRC EICGKCFPFQ GTLNQHLRKN HPGVAEVRSR IESPERTDVY VEQKLENDAS
   481  ASEMGLDSRM EIHTVSDAPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 14 nTPM
retina: 12 nTPM
placenta: 6.3 nTPM
spleen: 5 nTPM
lymph node: 4.5 nTPM
thymus: 4.5 nTPM

Single-cell type

neutrophils: 64 nCPM
platelets: 52 nCPM
late spermatids: 41 nCPM
neutrophil progenitors: 36 nCPM
cone photoreceptor cells: 27 nCPM
rod photoreceptor cells: 23 nCPM

Immune cell

neutrophil: 1.4 nTPM
eosinophil: 1 nTPM
basophil: 0.7 nTPM
NK-cell: 0.4 nTPM
classical monocyte: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM

Brain region

cerebellum: 16 nTPM
white matter: 14 nTPM
midbrain: 14 nTPM
thalamus: 13 nTPM
basal ganglia: 13 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 2.81
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB34 as an antibody target. Whether an autoantibody or antibody against ZBTB34 could matter depends on whether native ZBTB34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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