Seroatlas · Human Serome Atlas

KCTD14

BTB/POZ domain-containing protein KCTD14

Also known as: KCD14_HUMAN, MGC2376

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQ13
Gene: KCTD14
Ensembl: ENSG00000151364
Chromosome: 11
Canonical length: 255 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be involved in protein homooligomerization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>Q9BQ13|KCTD14
     1  MWQGCAVERP VGRMTSQTPL PQSPRPRRPT MSTVVELNVG GEFHTTTLGT LRKFPGSKLA
    61  EMFSSLAKAS TDAEGRFFID RPSTYFRPIL DYLRTGQVPT QHIPEVYREA QFYEIKPLVK
   121  LLEDMPQIFG EQVSRKQFLL QVPGYSENLE LMVRLARAEA ITARKSSVLV CLVETEEQDA
   181  YYSEVLCFLQ DKKMFKSVVK FGPWKAVLDN SDLMHCLEMD IKAQGYKVFS KFYLTYPTKR
   241  NEFHFNIYSF TFTWW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 27 nTPM
pancreas: 26 nTPM
adrenal gland: 22 nTPM
stomach: 20 nTPM
breast: 19 nTPM
seminal vesicle: 18 nTPM

Single-cell type

breast lactating cells: 50 nCPM
foveolar cells: 27 nCPM
epididymal principal cells: 26 nCPM
pancreatic acinar cells: 22 nCPM
epididymal efferent duct absorptive cells: 21 nCPM
alveolar cells type 2: 21 nCPM

Immune cell

memory CD8 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
myeloid DC: 0.2 nTPM
NK-cell: 0.2 nTPM
non-classical monocyte: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

cerebellum: 9.1 nTPM
choroid plexus: 5.3 nTPM
hypothalamus: 3.7 nTPM
midbrain: 3.5 nTPM
cerebral cortex: 3 nTPM
pons: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0
gnomAD missense Z: 0.08
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein homooligomerization

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD14 as an antibody target. Whether an autoantibody or antibody against KCTD14 could matter depends on whether native KCTD14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCTD14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...