Seroatlas · Human Serome Atlas

BTBD8

BTB/POZ domain-containing protein 8

Also known as: APache, BTBD8_HUMAN, KIAA1107

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5XKL5
Gene
BTBD8
Ensembl
ENSG00000189195
Chromosome
1
Canonical length
1792 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in synaptic vesicle budding from endosome and synaptic vesicle endocytosis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1792 residues, UniProt reviewed canonical sequence.

>Q5XKL5|BTBD8
     1  MARCGEGSAA PMVLLGSAGV CSKGLQRKGP CERRRLKATV SEQLSQDLLR LLREEFHTDV
    61  TFSVGCTLFK AHKAVLLARV PDFYFHTIGQ TSNSLTNQEP IAVENVEALE FRTFLQIIYS
   121  SNRNIKNYEE EILRKKIMEI GISQKQLDIS FPKCENSSDC SLQKHEIPED ISDRDDDFIS
   181  NDNYDLEPAS ELGEDLLKLY VKPCCPDIDI FVDGKRFKAH RAILSARSSY FAAMLSGCWA
   241  ESSQEYVTLQ GISHVELNVM MHFIYGGTLD IPDKTNVGQI LNMADMYGLE GLKEVAIYIL
   301  RRDYCNFFQK PVPRTLTSIL ECLIIAHSVG VESLFADCMK WIVKHFARFW SERSFANIPP
   361  EIQKSCLNML IQSLNDKNAA FLLMESDRLI ISLPRVKWTE AALTMASQLQ EKCIAFIVDN
   421  FSKIIQSENF ALLLQSQAMS STADLLDTIL KAIEENITTE NSCSLLMALD TLLNSDSTKE
   481  MGFTCKIQAL RDKLWIFLVQ SFYAVRHTES WKLMSTDDQQ KIQAAAFDKG DDRRLGKKPI
   541  FSSSQQRKQV SDSGDIKIKS WRGNNKKECW SYLSTNKKMK SDGLGASGHS SSTNRNSINK
   601  TLKQDDVKEK DGTKIASKIT KELKTGGKNV SGKPKTVTKS KTENGDKARL ENMSPRQVVE
   661  RSATAAAAAT GQKNLLNGKG VRNQEGQISG ARPKVLTGNL NVQAKAKPLK KATGKDSPCL
   721  SIAGPSSRST DSSMEFSIST ECLDEPKENG STEEEKPSGH KLSFCDSPGQ MMKNSVDSVK
   781  NSTVAIKSRP VSRVTNGTSN KKSIHEQDTN VNNSVLKKVS GKGCSEPVPQ AILKKRGTSN
   841  GCTAAQQRTK STPSNLTKTQ GSQGESPNSV KSSVSSRQSD ENVAKLDHNT TTEKQAPKRK
   901  MVKQVHTALP KVNAKIVAMP KNLNQSKKGE TLNNKDSKQK MPPGQVISKT QPSSQRPLKH
   961  ETSTVQKSMF HDVRDNNNKD SVSEQKPHKP LINLASEISD AEALQSSCRP DPQKPLNDQE
  1021  KEKLALECQN ISKLDKSLKH ELESKQICLD KSETKFPNHK ETDDCDAANI CCHSVGSDNV
  1081  NSKFYSTTAL KYMVSNPNEN SLNSNPVCDL DSTSAGQIHL ISDRENQVGR KDTNKQSSIK
  1141  CVEDVSLCNP ERTNGTLNSA QEDKKSKVPV EGLTIPSKLS DESAMDEDKH ATADSDVSSK
  1201  CFSGQLSEKN SPKNMETSES PESHETPETP FVGHWNLSTG VLHQRESPES DTGSATTSSD
  1261  DIKPRSEDYD AGGSQDDDGS NDRGISKCGT MLCHDFLGRS SSDTSTPEEL KIYDSNLRIE
  1321  VKMKKQSNND LFQVNSTSDD EIPRKRPEIW SRSAIVHSRE RENIPRGSVQ FAQEIDQVSS
  1381  SADETEDERS EAENVAENFS ISNPAPQQFQ GIINLAFEDA TENECREFSA TKKFKRSVLL
  1441  SVDECEELGS DEGEVHTPFQ ASVDSFSPSD VFDGISHEHH GRTCYSRFSR ESEDNILECK
  1501  QNKGNSVCKN ESTVLDLSSI DSSRKNKQSV SATEKKNTID VLSSRSRQLL REDKKVNNGS
  1561  NVENDIQQRS KFLDSDVKSQ ERPCHLDLHQ REPNSDIPKN SSTKSLDSFR SQVLPQEGPV
  1621  KESHSTTTEK ANIALSAGDI DDCDTLAQTR MYDHRPSKTL SPIYEMDVIE AFEQKVESET
  1681  HVTDMDFEDD QHFAKQDWTL LKQLLSEQDS NLDVTNSVPE DLSLAQYLIN QTLLLARDSS
  1741  KPQGITHIDT LNRWSELTSP LDSSASITMA SFSSEDCSPQ GEWTILELET QH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTBD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • retina: 17 nTPM
  • cerebral cortex: 13 nTPM
  • cerebellum: 8.5 nTPM
  • basal ganglia: 6 nTPM
  • testis: 4.8 nTPM
  • amygdala: 4.1 nTPM

Single-cell type

  • retinal bipolar cells: 212 nCPM
  • retinal amacrine cells: 197 nCPM
  • brain inhibitory neurons: 141 nCPM
  • somatotrophs: 120 nCPM
  • retinal ganglion cells: 116 nCPM
  • oligodendrocytes: 113 nCPM

Immune cell

  • naive CD4 T-cell: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 53 nTPM
  • white matter: 38 nTPM
  • cerebellum: 38 nTPM
  • basal ganglia: 33 nTPM
  • pons: 28 nTPM
  • thalamus: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTBD8 as an antibody target. Whether an autoantibody or antibody against BTBD8 could matter depends on whether native BTBD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTBD8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BTBD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BTBD8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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