Seroatlas · Human Serome Atlas

GMCL1

Germ cell-less protein-like 1

Also known as: BTBD13, FLJ13057, GCL1, GMCL1_HUMAN, SPATA29

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96IK5
Gene
GMCL1
Ensembl
ENSG00000087338
Chromosome
2
Canonical length
515 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila germ cell-less gene but the human genome also contains a single-exon locus on chromosome 5 that contains an open reading frame capable of encoding a highly-related protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

515 residues, UniProt reviewed canonical sequence.

>Q96IK5|GMCL1
     1  MGSLSSRVLR QPRPALAQQA QGARAGGSAR RPDTGDDAAG HGFCYCAGSH KRKRSSGSFC
    61  YCHPDSETDE DEEEGDEQQR LLNTPRRKKL KSTSKYIYQT LFLNGENSDI KICALGEEWS
   121  LHKIYLCQSG YFSSMFSGSW KESSMNIIEL EIPDQNIDVE ALQVAFGSLY RDDVLIKPSR
   181  VVAILAAACL LQLDGLIQQC GETMKETVNV KTVCGYYTSA GTYGLDSVKK KCLEWLLNNL
   241  MTHQNVELFK ELSINVMKQL IGSSNLFVMQ VEMDIYTALK KWMFLQLVPS WNGSLKQLLT
   301  ETDVWFSKQR KDFEGMAFLE TEQGKPFVSV FRHLRLQYII SDLASARIIE QDAVVPSEWL
   361  SSVYKQQWFA MLRAEQDSEV GPQEINKEEL EGNSMRCGRK LAKDGEYCWR WTGFNFGFDL
   421  LVTYTNRYII FKRNTLNQPC SGSVSLQPRR SIAFRLRLAS FDSSGKLICS RTTGYQILTL
   481  EKDQEQVVMN LDSRLLIFPL YICCNFLYIS PEKKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GMCL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 18 nTPM
  • thymus: 17 nTPM
  • testis: 15 nTPM
  • duodenum: 15 nTPM
  • bone marrow: 13 nTPM
  • small intestine: 12 nTPM

Single-cell type

  • early spermatids: 376 nCPM
  • neutrophil progenitors: 188 nCPM
  • cholangiocytes: 186 nCPM
  • neutrophils: 160 nCPM
  • syncytiotrophoblasts: 160 nCPM
  • extravillous trophoblasts: 127 nCPM

Immune cell

  • basophil: 94 nTPM
  • eosinophil: 40 nTPM
  • NK-cell: 27 nTPM
  • neutrophil: 27 nTPM
  • MAIT T-cell: 19 nTPM
  • naive CD4 T-cell: 16 nTPM

Brain region

  • choroid plexus: 23 nTPM
  • cerebellum: 9.7 nTPM
  • white matter: 9.6 nTPM
  • hippocampal formation: 9.4 nTPM
  • cerebral cortex: 9.1 nTPM
  • midbrain: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
1.21
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GMCL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GMCL1 as an antibody target. Whether an autoantibody or antibody against GMCL1 could matter depends on whether native GMCL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GMCL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GMCL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GMCL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...