Seroatlas · Human Serome Atlas

ZBTB20

Zinc finger and BTB domain-containing protein 20

Also known as: DKFZp566F123, DPZF, ODA-8S, ZBT20_HUMAN, ZNF288

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HC78
Gene
ZBTB20
Ensembl
ENSG00000181722
Chromosome
3
Canonical length
741 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nuclear bodies
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

741 residues, UniProt reviewed canonical sequence.

>Q9HC78|ZBTB20
     1  MLERKKPKTA ENQKASEENE ITQPGGSSAK PGLPCLNFEA VLSPDPALIH STHSLTNSHA
    61  HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR GHFCDVTVRI HGSMLRAHRC
   121  VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS VQKLIDFMYS GVLRVSQSEA LQILTAASIL
   181  QIKTVIDECT RIVSQNVGDV FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV
   241  DRIYSALYAC SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER
   301  YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER NESEECTEDT
   361  DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGPGAAR DSQAEPTQPE QAAEAPAEGG
   421  PQTNQLETGA SSPERSNEVE MDSTVITVSN SSDKSVLQQP SVNTSIGQPL PSTQLYLRQT
   481  ETLTSNLRMP LTLTSNTQVI GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLAGQQTQFV
   541  TVSQPGLSTF TAQLPAPQPL ASSAGHSTAS GQGEKKPYEC TLCNKTFTAK QNYVKHMFVH
   601  TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN VHMRLHRGEK
   661  SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR AGPPGVVACT EGTTYVCSVC
   721  PAKFDQIEQF NDHMRMHVSD G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • epididymis: 9.2 nTPM
  • tongue: 8.3 nTPM
  • retina: 8.2 nTPM
  • skeletal muscle: 7.7 nTPM
  • liver: 5.2 nTPM

Single-cell type

  • corticotrophs: 4,323 nCPM
  • renal collecting duct intercalated cells: 4,215 nCPM
  • myonuclei: 4,135 nCPM
  • proximal tubule cells: 3,774 nCPM
  • bergmann glia: 3,501 nCPM
  • lactotrophs: 3,159 nCPM

Immune cell

  • memory B-cell: 16 nTPM
  • basophil: 14 nTPM
  • naive B-cell: 11 nTPM
  • naive CD4 T-cell: 8.4 nTPM
  • gdT-cell: 6.9 nTPM
  • naive CD8 T-cell: 6.9 nTPM

Brain region

  • cerebellum: 169 nTPM
  • hippocampal formation: 167 nTPM
  • medulla oblongata: 135 nTPM
  • basal ganglia: 130 nTPM
  • midbrain: 129 nTPM
  • white matter: 129 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZBTB20.

Disease | AllUniProt

Conditions ZBTB20 is implicated in, by any mechanism.

Disease | GeneticClinVar

89 pathogenic / likely-pathogenic of 465 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
4.27
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB20 as an antibody target. Whether an autoantibody or antibody against ZBTB20 could matter depends on whether native ZBTB20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZBTB20. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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