HIC2
Hypermethylated in cancer 2 protein
Also known as: HIC2_HUMAN, HRG22, KIAA1020, ZBTB30, ZNF907
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96JB3
- Gene
- HIC2
- Ensembl
- ENSG00000169635
- Chromosome
- 22
- Canonical length
- 615 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
615 residues, UniProt reviewed canonical sequence.
>Q96JB3|HIC2
1 MVSGPLALRW CAWAGRGDMG PDMELPSHSK QLLLQLNQQR TKGFLCDVII MVENSIFRAH
61 KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI YTGKLLPSDQ PAEPNFSTLL
121 TAASYLQLPE LAALCRRKLK RAGKPFGSGR AGSTGMGRPP RSQRLSTASV IQARYQGLVD
181 GRKGAHAPQE LPQAKGSDDE LFLGGSNQDS VQGLGRAVCP AGGEAGLGGC SSSTNGSSGG
241 CEQELGLDLS KKSPPLPPAT PGPHLTPDDA AQLSDSQHGS PPAASAPPVA NSASYSELGG
301 TPDEPMDLEG AEDNHLSLLE APGGQPRKSL RHSTRKKEWG KKEPVAGSPF ERREAGPKGP
361 CPGEEGEGVG DRVPNGILAS GAGPSGPYGE PPYPCKEEEE NGKDASEDSA QSGSEGGSGH
421 ASAHYMYRQE GYETVSYGDN LYVCIPCAKG FPSSEQLNAH VETHTEEELF IKEEGAYETG
481 SGGAEEEAED LSAPSAAYTA EPRPFKCSVC EKTYKDPATL RQHEKTHWLT RPFPCNICGK
541 MFTQRGTMTR HMRSHLGLKP FACDECGMRF TRQYRLTEHM RVHSGEKPYE CQLCGGKFTQ
601 QRNLISHLRM HTSPSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HIC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 7 nTPM
Expression across tissuesHPA
Tissue
- testis: 7 nTPM
- placenta: 5.5 nTPM
- basal ganglia: 4.7 nTPM
- cerebral cortex: 3.6 nTPM
- bone marrow: 3.5 nTPM
- ovary: 3.3 nTPM
Single-cell type
- extravillous trophoblasts: 52 nCPM
- late spermatids: 52 nCPM
- cytotrophoblasts: 50 nCPM
- migrating cytotrophoblasts: 47 nCPM
- syncytiotrophoblasts: 46 nCPM
- renal collecting duct intercalated cells: 37 nCPM
Immune cell
- plasmacytoid DC: 0.3 nTPM
- MAIT T-cell: 0.2 nTPM
- memory B-cell: 0.2 nTPM
- memory CD4 T-cell: 0.2 nTPM
- naive CD4 T-cell: 0.2 nTPM
- non-classical monocyte: 0.2 nTPM
Brain region
- cerebral cortex: 9.8 nTPM
- basal ganglia: 9.4 nTPM
- amygdala: 9.3 nTPM
- hippocampal formation: 7.1 nTPM
- white matter: 6.9 nTPM
- hypothalamus: 6.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.18
- gnomAD pLI
- 1
- gnomAD missense Z
- 2.05
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of DNA-templated transcription
- negative regulation of transcription by RNA polymerase II
- regulation of cytokine production
- regulation of immune system process
Molecular functions
- DNA binding
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of HIC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HIC2 as an antibody target. Whether an autoantibody or antibody against HIC2 could matter depends on whether native HIC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HIC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HIC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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