Seroatlas · Human Serome Atlas

KBTBD4

Kelch repeat and BTB domain-containing protein 4

Also known as: BKLHD4, FLJ10450, HSPC252, KBTB4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NVX7
Gene
KBTBD4
Ensembl
ENSG00000123444
Chromosome
11
Canonical length
534 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

No narrative summary is available for KBTBD4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

534 residues, UniProt reviewed canonical sequence.

>Q9NVX7|KBTBD4
     1  MKGGNADSWQ REKLASMESP EEPGASMDEN YFVNYTFKDR SHSGRVAQGI MKLCLEEELF
    61  ADVTISVEGR EFQLHRLVLS AQSCFFRSMF TSNLKEAHNR VIVLQDVSES VFQLLVDYIY
   121  HGTVKLRAEE LQEIYEVSDM YQLTSLFEEC SRFLARTVQV GNCLQVMWLA DRHSDPELYT
   181  AAKHCAKTHL AQLQNTEEFL HLPHRLLTDI ISDGVPCSQN PTEAIEAWIN FNKEEREAFA
   241  ESLRTSLKEI GENVHIYLIG KESSRTHSLA VSLHCAEDDS ISVSGQNSLC HQITAACKHG
   301  GDLYVVGGSI PRRMWKCNNA TVDWEWCAPL PRDRLQHTLV SVPGKDAIYS LGGKTLQDTL
   361  SNAVIYYRVG DNVWTETTQL EVAVSGAAGA NLNGIIYLLG GEENDLDFFT KPSRLIQCFD
   421  TETDKCHVKP YVLPFAGRMH AAVHKDLVFI VAEGDSLVCY NPLLDSFTRL CLPEAWSSAP
   481  SLWKIASCNG SIYVFRDRYK KGDANTYKLD PATSAVTVTR GIKVLLTNLQ FVLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KBTBD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 20 nTPM
  • cerebellum: 14 nTPM
  • parathyroid gland: 12 nTPM
  • tongue: 10 nTPM
  • skin: 10 nTPM
  • adrenal gland: 10 nTPM

Single-cell type

  • other brain neurons: 8.9 nCPM
  • brain inhibitory neurons: 8.5 nCPM
  • brain excitatory neurons: 8.3 nCPM
  • bergmann glia: 7.7 nCPM
  • ependymal cells: 6.9 nCPM
  • oligodendrocytes: 5.1 nCPM

Immune cell

  • MAIT T-cell: 14 nTPM
  • NK-cell: 14 nTPM
  • T-reg: 13 nTPM
  • gdT-cell: 13 nTPM
  • basophil: 12 nTPM
  • eosinophil: 12 nTPM

Brain region

  • cerebellum: 9.7 nTPM
  • choroid plexus: 8.1 nTPM
  • basal ganglia: 7.6 nTPM
  • cerebral cortex: 7 nTPM
  • white matter: 6.9 nTPM
  • midbrain: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
1.26
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KBTBD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KBTBD4 as an antibody target. Whether an autoantibody or antibody against KBTBD4 could matter depends on whether native KBTBD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KBTBD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KBTBD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KBTBD4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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