NACC2
Nucleus accumbens-associated protein 2
Also known as: BEND9, BTBD14A, BTBD31, MGC23427, NACC2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96BF6
- Gene
- NACC2
- Ensembl
- ENSG00000148411
- Chromosome
- 9
- Canonical length
- 587 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli,Mitochondria
- Quaternary structure
- Homooligomer
OverviewNCBI Gene
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein homooligomerization. Located in chromatin; mitochondrion; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
587 residues, UniProt reviewed canonical sequence.
>Q96BF6|NACC2
1 MSQMLHIEIP NFGNTVLGCL NEQRLLGLYC DVSIVVKGQA FKAHRAVLAA SSLYFRDLFS
61 GNSKSAFELP GSVPPACFQQ ILSFCYTGRL TMTASEQLVV MYTAGFLQIQ HIVERGTDLM
121 FKVSSPHCDS QTAVIEDAGS EPQSPCNQLQ PAAAAAAPYV VSPSVPIPLL TRVKHEAMEL
181 PPAGPGLAPK RPLETGPRDG VAVAAGAAVA AGTAPLKLPR VSYYGVPSLA TLIPGIQQMP
241 YPQGERTSPG ASSLPTTDSP TSYHNEEDEE DDEAYDTMVE EQYGQMYIKA SGSYAVQEKP
301 EPVPLESRSC VLIRRDLVAL PASLISQIGY RCHPKLYSEG DPGEKLELVA GSGVYITRGQ
361 LMNCHLCAGV KHKVLLRRLL ATFFDRNTLA NSCGTGIRSS TSDPSRKPLD SRVLNAVKLY
421 CQNFAPSFKE SEMNVIAADM CTNARRVRKR WLPKIKSMLP EGVEMYRTVM GSAAASVPLD
481 PEFPPAAAQV FEQRIYAERR GDAATIVALR TDAVNVDLSA AANPAFDAGE EVDGAGSVIQ
541 EVAAPEPLPA DGQSPPQPFE QGGGGPSRPQ TPAAAARRPE GTYAGTLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against NACC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 62 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 62 nTPM
- midbrain: 55 nTPM
- amygdala: 51 nTPM
- basal ganglia: 50 nTPM
- cerebral cortex: 44 nTPM
- hippocampal formation: 38 nTPM
Single-cell type
- late spermatids: 456 nCPM
- neutrophils: 120 nCPM
- early spermatids: 104 nCPM
- monocyte progenitors: 97 nCPM
- choroid plexus epithelial cells: 96 nCPM
- monocytes: 86 nCPM
Immune cell
- neutrophil: 2.7 nTPM
- classical monocyte: 2.2 nTPM
- basophil: 1.9 nTPM
- intermediate monocyte: 1.7 nTPM
- non-classical monocyte: 1.7 nTPM
- myeloid DC: 1.2 nTPM
Brain region
- thalamus: 257 nTPM
- cerebellum: 248 nTPM
- pons: 245 nTPM
- medulla oblongata: 241 nTPM
- midbrain: 224 nTPM
- basal ganglia: 213 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.75
- gnomAD pLI
- 0.31
- gnomAD missense Z
- 1.73
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of cell population proliferation
- negative regulation of DNA-templated transcription
- negative regulation of transcription by RNA polymerase II
- positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
- protein homooligomerization
- protein-containing complex localization
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- histone deacetylase binding
- protein homodimerization activity
- protein-containing complex binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NACC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NACC2 as an antibody target. Whether an autoantibody or antibody against NACC2 could matter depends on whether native NACC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NACC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NACC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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