Seroatlas · Human Serome Atlas

IPP

Actin-binding protein IPP

Also known as: IPP_HUMAN, KLHL27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y573
Gene
IPP
Ensembl
ENSG00000197429
Chromosome
1
Canonical length
584 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

584 residues, UniProt reviewed canonical sequence.

>Q9Y573|IPP
     1  MANEDCPKAA DSPFSSDKHA QLILAQINKM RNGQHFCDVQ LQVGQESFKA HRLVLAASSP
    61  YFAALFTGGM KESSKDVVPI LGIEAGIFQI LLDFIYTGIV NIGVNNVQEL IIAADMLQLT
   121  EVVHLCCEFL KGQIDPLNCI GIFQFSEQIA CHDLLEFSEN YIHVHFLEVH SGEEFLALTK
   181  DQLIKILRSE ELSIEDEYQV FLAAMQWILK DLGKRRKHVV EVLDPIRFPL LPPQRLLKYI
   241  EGVSDFNLRV ALQTLLKEYC EVCKSPKENK FCSFLQTSKV RPRKKARKYL YAVGGYTRLQ
   301  GGRWSDSRAL SCVERFDTFS QYWTTVSSLH QARSGLGVTV LGGMVYAIGG EKDSMIFDCT
   361  ECYDPVTKQW TTVASMNHPR CGLGVCVCYG AIYALGGWVG AEIGNTIERF DPDENKWEVV
   421  GNMAVSRYYF GCCEMQGLIY VIGGISNEGI ELRSFEVYDP LSKRWSPLPP MGTRRAYLGV
   481  AALNDCIYSV GGWNETQDAL HTVEKYSFEE EKWVEVASMK VPRAGMCVVA VNGLLYVSGG
   541  RSSSHDFLAP GTLDSVEVYN PHSDTWTEIG NMITSRCEGG VAVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IPP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 13 nTPM
  • testis: 9.5 nTPM
  • thyroid gland: 9.1 nTPM
  • parathyroid gland: 8.9 nTPM
  • tongue: 8.4 nTPM
  • retina: 6.8 nTPM

Single-cell type

  • myonuclei: 53 nCPM
  • late primary spermatocytes: 53 nCPM
  • podocytes: 49 nCPM
  • neutrophils: 47 nCPM
  • early primary spermatocytes: 46 nCPM
  • renal connecting tubule cells: 42 nCPM

Immune cell

  • T-reg: 4.7 nTPM
  • gdT-cell: 4.6 nTPM
  • basophil: 4.1 nTPM
  • naive CD8 T-cell: 4 nTPM
  • NK-cell: 3.8 nTPM
  • memory CD8 T-cell: 3.7 nTPM

Brain region

  • white matter: 14 nTPM
  • basal ganglia: 13 nTPM
  • hypothalamus: 13 nTPM
  • cerebellum: 12 nTPM
  • midbrain: 12 nTPM
  • medulla oblongata: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0
gnomAD missense Z
0.5
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IPP as an antibody target. Whether an autoantibody or antibody against IPP could matter depends on whether native IPP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IPP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IPP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IPP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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