Seroatlas · Human Serome Atlas

KLHL6

Kelch-like protein 6

Also known as: FLJ00029, KLHL6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WZ60
Gene
KLHL6
Ensembl
ENSG00000172578
Chromosome
3
Canonical length
621 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Microtubules,Mitotic spindle,Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

621 residues, UniProt reviewed canonical sequence.

>Q8WZ60|KLHL6
     1  MLMAGQRGAW TMGDVVEKSL EGPLAPSTDE PSQKTGDLVE ILNGEKVKFD DAGLSLILQN
    61  GLETLRMENA LTDVILCVDI QEFSCHRVVL AAASNYFRAM FCNDLKEKYE KRIIIKGVDA
   121  ETMHTLLDYT YTSKALITKQ NVQRVLEAAN LFQFLRMVDA CASFLTEALN PENCVGILRL
   181  ADTHSLDSLK KQVQSYIIQN FVQILNSEEF LDLPVDTLHH ILKSDDLYVT EEAQVFETVM
   241  SWVRHKPSER LCLLPYVLEN VRLPLLDPWY FVETVEADPL IRQCPEVFPL LQEARMYHLS
   301  GNEIISERTK PRMHEFQSEV FMIIGGCTKD ERFVAEVTCL DPLRRSRLEV AKLPLTEHEL
   361  ESENKKWVEF ACVTLKNEVY ISGGKETQHD VWKYNSSINK WIQIEYLNIG RWRHKMVVLG
   421  GKVYVIGGFD GLQRINNVET YDPFHNCWSE AAPLLVHVSS FAATSHKKKL YVIGGGPNGK
   481  LATDKTQCYD PSTNKWSLKA AMPVEAKCIN AVSFRDRIYV VGGAMRALYA YSPLEDSWCL
   541  VTQLSHERAS CGIAPCNNRL YITGGRDEKN EVIATVLCWD PEAQKLTEEC VLPRGVSHHG
   601  SVTIRKSYTH IRRIVPGAVS V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 29 nTPM
  • lymph node: 27 nTPM
  • appendix: 11 nTPM
  • thymus: 9.3 nTPM
  • spleen: 5.9 nTPM
  • fallopian tube: 4.5 nTPM

Single-cell type

  • plasma cells: 285 nCPM
  • platelets: 168 nCPM
  • macrophages: 135 nCPM
  • b-cells: 134 nCPM
  • cdc: 127 nCPM
  • innate lymphoid cells: 109 nCPM

Immune cell

  • eosinophil: 12 nTPM
  • basophil: 7.6 nTPM
  • plasmacytoid DC: 4.3 nTPM
  • T-reg: 4.1 nTPM
  • memory B-cell: 3.4 nTPM
  • naive CD4 T-cell: 2.8 nTPM

Brain region

  • white matter: 7.6 nTPM
  • thalamus: 6.6 nTPM
  • medulla oblongata: 5.5 nTPM
  • pons: 4.2 nTPM
  • spinal cord: 3.4 nTPM
  • hypothalamus: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
1.24
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL6 as an antibody target. Whether an autoantibody or antibody against KLHL6 could matter depends on whether native KLHL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHL6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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