ZBTB8A
Zinc finger and BTB domain-containing protein 8A
Also known as: BOZF1, FLJ90065, ZBT8A_HUMAN, ZBTB8, ZNF916A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96BR9
- Gene
- ZBTB8A
- Ensembl
- ENSG00000160062
- Chromosome
- 1
- Canonical length
- 441 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nuclear speckles,Focal adhesion sites
OverviewNCBI Gene
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
441 residues, UniProt reviewed canonical sequence.
>Q96BR9|ZBTB8A
1 MEISSHQSHL LQQLNEQRRQ DVFCDCSILV EGKVFKAHRN VLFASSGYFK MLLSQNSKET
61 SQPTTATFQA FSPDTFTVIL DFVYSGKLSL TGQNVIEVMS AASFLQMTDV ISVCKTFIKS
121 SLDISEKEKD RYFSLSDKDA NSNGVERSSF YSGGWQEGSS SPRSHLSPEQ GTGIISGKSW
181 NKYNYHPASQ KNTQQPLAKH EPRKESIKKT KHLRLSQPSE VTHYKSSKRE VRTSDSSSHV
241 SQSEEQAQID AEMDSTPVGY QYGQGSDVTS KSFPDDLPRM RFKCPYCTHV VKRKADLKRH
301 LRCHTGERPY PCQACGKRFS RLDHLSSHFR TIHQACKLIC RKCKRHVTDL TGQVVQEGTR
361 RYRLCNECLA EFGIDSLPID LEAEQHLMSP SDGDKDSRWH LSEDENRSYV EIVEDGSADL
421 VIQQVDDSEE EEEKEIKPNI RLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZBTB8A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 5.9 nTPM
Expression across tissuesHPA
Tissue
- cervix: 5.9 nTPM
- tongue: 5.8 nTPM
- endometrium: 5.7 nTPM
- thyroid gland: 5.1 nTPM
- smooth muscle: 4.7 nTPM
- seminal vesicle: 3.8 nTPM
Single-cell type
- peritubular myoid cells: 30 nCPM
- hematopoietic stem cells: 27 nCPM
- endometrial stromal cells: 24 nCPM
- leydig cells: 24 nCPM
- vascular endothelial cells: 19 nCPM
- decidual stromal cells: 17 nCPM
Immune cell
- basophil: 1.2 nTPM
- neutrophil: 0.8 nTPM
- NK-cell: 0.6 nTPM
- plasmacytoid DC: 0.5 nTPM
- naive B-cell: 0.3 nTPM
- classical monocyte: 0.2 nTPM
Brain region
- cerebellum: 10 nTPM
- white matter: 8 nTPM
- cerebral cortex: 6.6 nTPM
- medulla oblongata: 6.5 nTPM
- amygdala: 6.3 nTPM
- pons: 6.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.74
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.74
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II-specific DNA-binding transcription factor binding
- transcription cis-regulatory region binding
- transcription coactivator binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZBTB8A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZBTB8A as an antibody target. Whether an autoantibody or antibody against ZBTB8A could matter depends on whether native ZBTB8A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZBTB8A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZBTB8A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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