Seroatlas · Human Serome Atlas

KCNS2

Delayed-rectifier potassium channel regulatory subunit KCNS2

Also known as: KCNS2_HUMAN, Kv9.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULS6
Gene
KCNS2
Ensembl
ENSG00000156486
Chromosome
8
Canonical length
477 aa
Protein class
Predicted membrane proteins, Transporters, Voltage-gated ion channels
Quaternary structure
Homomultimer

OverviewNCBI Gene

Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of potassium ion transmembrane transport. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>Q9ULS6|KCNS2
     1  MTGQSLWDVS EANVEDGEIR INVGGFKRRL RSHTLLRFPE TRLGRLLLCH SREAILELCD
    61  DYDDVQREFY FDRNPELFPY VLHFYHTGKL HVMAELCVFS FSQEIEYWGI NEFFIDSCCS
   121  YSYHGRKVEP EQEKWDEQSD QESTTSSFDE ILAFYNDASK FDGQPLGNFR RQLWLALDNP
   181  GYSVLSRVFS ILSILVVMGS IITMCLNSLP DFQIPDSQGN PGEDPRFEIV EHFGIAWFTF
   241  ELVARFAVAP DFLKFFKNAL NLIDLMSIVP FYITLVVNLV VESTPTLANL GRVAQVLRLM
   301  RIFRILKLAR HSTGLRSLGA TLKYSYKEVG LLLLYLSVGI SIFSVVAYTI EKEENEGLAT
   361  IPACWWWATV SMTTVGYGDV VPGTTAGKLT ASACILAGIL VVVLPITLIF NKFSHFYRRQ
   421  KQLESAMRSC DFGDGMKEVP SVNLRDYYAH KVKSLMASLT NMSRSSPSEL SLNDSLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
4 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 4 nTPM
  • placenta: 1.4 nTPM
  • seminal vesicle: 0.9 nTPM
  • amygdala: 0.8 nTPM
  • hypothalamus: 0.8 nTPM
  • urinary bladder: 0.8 nTPM

Single-cell type

  • decidual stromal cells: 8.5 nCPM
  • retinal amacrine cells: 4.1 nCPM
  • brain inhibitory neurons: 4 nCPM
  • brain excitatory neurons: 3.6 nCPM
  • endometrial stromal cells: 2.6 nCPM
  • other brain neurons: 2.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 21 nTPM
  • white matter: 13 nTPM
  • basal ganglia: 9.3 nTPM
  • spinal cord: 8.6 nTPM
  • hypothalamus: 8 nTPM
  • amygdala: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0.06
gnomAD missense Z
1.65
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNS2 as an antibody target. Whether an autoantibody or antibody against KCNS2 could matter depends on whether native KCNS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNS2 is annotated at the cell surface, where native KCNS2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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