Seroatlas · Human Serome Atlas

ZBTB1

Zinc finger and BTB domain-containing protein 1

Also known as: KIAA0997, ZBTB1_HUMAN, ZNF909

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2K1
Gene: ZBTB1
Ensembl: ENSG00000126804
Chromosome: 14
Canonical length: 713 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables K63-linked polyubiquitin modification-dependent protein binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nucleobase-containing compound biosynthetic process; and protein homooligomerization. Located in nuclear body and nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

713 residues, UniProt reviewed canonical sequence.

>Q9Y2K1|ZBTB1
     1  MAKPSHSSYV LQQLNNQREW GFLCDCCIAI DDIYFQAHKA VLAACSSYFR MFFMNHQHST
    61  AQLNLSNMKI SAECFDLILQ FMYLGKIMTA PSSFEQFKVA MNYLQLYNVP DCLEDIQDAD
   121  CSSSKCSSSA SSKQNSKMIF GVRMYEDTVA RNGNEANRWC AEPSSTVNTP HNREADEESL
   181  QLGNFPEPLF DVCKKSSVSK LSTPKERVSR RFGRSFTCDS CGFGFSCEKL LDEHVLTCTN
   241  RHLYQNTRSY HRIVDIRDGK DSNIKAEFGE KDSSKTFSAQ TDKYRGDTSQ AADDSASTTG
   301  SRKSSTVESE IASEEKSRAA ERKRIIIKME PEDIPTDELK DFNIIKVTDK DCNESTDNDE
   361  LEDEPEEPFY RYYVEEDVSI KKSGRKTLKP RMSVSADERG GLENMRPPNN SSPVQEDAEN
   421  ASCELCGLTI TEEDLSSHYL AKHIENICAC GKCGQILVKG RQLQEHAQRC GEPQDLTMNG
   481  LGNTEEKMDL EENPDEQSEI RDMFVEMLDD FRDNHYQINS IQKKQLFKHS ACPFRCPNCG
   541  QRFETENLVV EHMSSCLDQD MFKSAIMEEN ERDHRRKHFC NLCGKGFYQR CHLREHYTVH
   601  TKEKQFVCQT CGKQFLRERQ LRLHNDMHKG MARYVCSICD QGNFRKHDHV RHMISHLSAG
   661  ETICQVCFQI FPNNEQLEQH MDVHLYTCGI CGAKFNLRKD MRSHYNAKHL KRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 76 nTPM
lymph node: 39 nTPM
thymus: 35 nTPM
skin: 32 nTPM
tonsil: 32 nTPM
spleen: 32 nTPM

Single-cell type

innate lymphoid cells: 262 nCPM
neutrophils: 248 nCPM
prostatic glandular cells: 221 nCPM
nk-cells: 212 nCPM
thymocytes: 203 nCPM
t-cells: 186 nCPM

Immune cell

basophil: 42 nTPM
T-reg: 26 nTPM
eosinophil: 23 nTPM
MAIT T-cell: 21 nTPM
naive CD8 T-cell: 21 nTPM
memory CD8 T-cell: 21 nTPM

Brain region

white matter: 44 nTPM
thalamus: 42 nTPM
choroid plexus: 42 nTPM
medulla oblongata: 40 nTPM
basal ganglia: 39 nTPM
spinal cord: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.99
gnomAD missense Z: 2.97
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZBTB25

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB1 as an antibody target. Whether an autoantibody or antibody against ZBTB1 could matter depends on whether native ZBTB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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