Seroatlas · Human Serome Atlas

KCTD9

BTB/POZ domain-containing protein KCTD9

Also known as: BTBD27, FLJ20038, KCTD9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L273
Gene
KCTD9
Ensembl
ENSG00000104756
Chromosome
8
Canonical length
389 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Intermediate filaments,Cytosol

OverviewNCBI Gene

Enables cullin family protein binding activity and identical protein binding activity. Predicted to be involved in intracellular signal transduction; protein homooligomerization; and protein ubiquitination. Predicted to act upstream of or within several processes, including NK T cell lineage commitment; natural killer cell activation; and response to virus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q7L273|KCTD9
     1  MRRVTLFLNG SPKNGKVVAV YGTLSDLLSV ASSKLGIKAT SVYNGKGGLI DDIALIRDDD
    61  VLFVCEGEPF IDPQTDSKPP EGLLGFHTDW LTLNVGGRYF TTTRSTLVNK EPDSMLAHMF
   121  KDKGVWGNKQ DHRGAFLIDR SPEYFEPILN YLRHGQLIVN DGINLLGVLE EARFFGIDSL
   181  IEHLEVAIKN SQPPEDHSPI SRKEFVRFLL ATPTKSELRC QGLNFSGADL SRLDLRYINF
   241  KMANLSRCNL AHANLCCANL ERADLSGSVL DCANLQGVKM LCSNAEGASL KLCNFEDPSG
   301  LKANLEGANL KGVDMEGSQM TGINLRVATL KNAKLKNCNL RGATLAGTDL ENCDLSGCDL
   361  QEANLRGSNV KGAIFEEMLT PLHMSQSVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 36 nTPM
  • tongue: 34 nTPM
  • blood vessel: 34 nTPM
  • skeletal muscle: 28 nTPM
  • esophagus: 22 nTPM
  • rectum: 21 nTPM

Single-cell type

  • innate lymphoid cells: 165 nCPM
  • esophageal apical cells: 160 nCPM
  • thymocytes: 147 nCPM
  • peritubular myoid cells: 129 nCPM
  • basal keratinocytes: 120 nCPM
  • suprabasal keratinocytes: 107 nCPM

Immune cell

  • eosinophil: 1.2 nTPM
  • T-reg: 1.1 nTPM
  • gdT-cell: 1 nTPM
  • MAIT T-cell: 1 nTPM
  • memory CD4 T-cell: 1 nTPM
  • memory CD8 T-cell: 1 nTPM

Brain region

  • pons: 21 nTPM
  • medulla oblongata: 19 nTPM
  • choroid plexus: 18 nTPM
  • cerebellum: 17 nTPM
  • spinal cord: 17 nTPM
  • midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.06
gnomAD missense Z
3.6
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCTD9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD9 as an antibody target. Whether an autoantibody or antibody against KCTD9 could matter depends on whether native KCTD9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCTD9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCTD9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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