Seroatlas · Human Serome Atlas

KLHL14

Kelch-like protein 14

Also known as: KIAA1384, KLH14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2G3
Gene: KLHL14
Ensembl: ENSG00000197705
Chromosome: 18
Canonical length: 628 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the Kelch-like gene family, whose members contain a BTB/POZ domain, a BACK domain, and several Kelch domains. The encoded protein possesses six Kelch domains and localizes to the endoplasmic reticulum, where it interacts with torsin-1A. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

628 residues, UniProt reviewed canonical sequence.

>Q9P2G3|KLHL14
     1  MSRSGDRTST FDPSHSDNLL HGLNLLWRKQ LFCDVTLTAQ GQQFHCHKAV LASCSQYFRS
    61  LFSSHPPLGG GVGGQDGLGA PKDQQQPPQQ QPSQQQQPPP QEEPGTPSSS PDDKLLTSPR
   121  AINNLVLQGC SSIGLRLVLE YLYTANVTLS LDTVEEVLSV SKILHIPQVT KLCVQFLNDQ
   181  ISVQNYKQVC KIAALHGLEE TKKLANKYLV EDVLLLNFEE MRALLDSLPP PVESELALFQ
   241  MSVLWLEHDR ETRMQYAPDL MKRLRFALIP APELVERVQS VDFMRTDPVC QKLLLDAMNY
   301  HLMPFRQHCR QSLASRIRSN KKMLLLVGGL PPGPDRLPSN LVQYYDDEKK TWKILTIMPY
   361  NSAHHCVVEV ENFLFVLGGE DQWNPNGKHS TNFVSRYDPR FNSWIQLPPM QERRASFYAC
   421  RLDKHLYVIG GRNETGYLSS VECYNLETNE WRYVSSLPQP LAAHAGAVHN GKIYISGGVH
   481  NGEYVPWLYC YDPVMDVWAR KQDMNTKRAI HTLAVMNDRL YAIGGNHLKG FSHLDVMLVE
   541  CYDPKGDQWN ILQTPILEGR SGPGCAVLDD SIYLVGGYSW SMGAYKSSTI CYCPEKGTWT
   601  ELEGDVAEPL AGPACVTVIL PSCVPYNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 13 nTPM
seminal vesicle: 12 nTPM
spleen: 8.2 nTPM
lymph node: 6.7 nTPM
parathyroid gland: 6.5 nTPM
fallopian tube: 6.2 nTPM

Single-cell type

b-cells: 80 nCPM
loop of henle epithelial cells: 79 nCPM
renal collecting duct principal cells: 75 nCPM
müller glia: 59 nCPM
plasma cells: 58 nCPM
endometrial ciliated cells: 49 nCPM

Immune cell

memory B-cell: 11 nTPM
naive B-cell: 7.3 nTPM
total PBMC: 0.5 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

midbrain: 5.4 nTPM
medulla oblongata: 3.4 nTPM
spinal cord: 2.3 nTPM
pons: 1.9 nTPM
cerebral cortex: 1.8 nTPM
hippocampal formation: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.05
gnomAD missense Z: 1.6
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHL14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TOR1A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL14 as an antibody target. Whether an autoantibody or antibody against KLHL14 could matter depends on whether native KLHL14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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