Seroatlas · Human Serome Atlas

KCTD11

BTB/POZ domain-containing protein KCTD11

Also known as: C17orf36, KCASH1, KCD11_HUMAN, REN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q693B1
Gene: KCTD11
Ensembl: ENSG00000213859
Chromosome: 17
Canonical length: 232 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homopentamer

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in positive regulation of neuron differentiation. Predicted to act upstream of or within negative regulation of neuroblast proliferation; negative regulation of smoothened signaling pathway; and nervous system development. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

232 residues, UniProt reviewed canonical sequence.

>Q693B1|KCTD11
     1  MLGAMFRAGT PMPPNLNSQG GGHYFIDRDG KAFRHILNFL RLGRLDLPRG YGETALLRAE
    61  ADFYQIRPLL DALRELEASQ GTPAPTAALL HADVDVSPRL VHFSARRGPH HYELSSVQVD
   121  TFRANLFCTD SECLGALRAR FGVASGDRAE GSPHFHLEWA PRPVELPEVE YGRLGLQPLW
   181  TGGPGERREV VGTPSFLEEV LRVALEHGFR LDSVFPDPED LLNSRSLRFV RH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

esophagus: 39 nTPM
vagina: 35 nTPM
skin: 33 nTPM
cervix: 32 nTPM
urinary bladder: 27 nTPM
salivary gland: 15 nTPM

Single-cell type

papillary tip epithelial cells: 5.3 nCPM
podocytes: 4.9 nCPM
ependymal cells: 3.8 nCPM
microglia: 2.6 nCPM
choroid plexus epithelial cells: 2.3 nCPM
oligodendrocytes: 2.2 nCPM

Immune cell

basophil: 9.5 nTPM
intermediate monocyte: 3.5 nTPM
non-classical monocyte: 2.9 nTPM
classical monocyte: 2.6 nTPM
total PBMC: 1.9 nTPM
eosinophil: 1.6 nTPM

Brain region

thalamus: 8.5 nTPM
medulla oblongata: 7.6 nTPM
choroid plexus: 6.2 nTPM
white matter: 6.2 nTPM
cerebellum: 5.9 nTPM
spinal cord: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0.01
gnomAD missense Z: 1.23
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCTD11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD11 as an antibody target. Whether an autoantibody or antibody against KCTD11 could matter depends on whether native KCTD11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCTD11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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