Seroatlas · Human Serome Atlas

KCNS1

Delayed-rectifier potassium channel regulatory subunit KCNS1

Also known as: KCNS1_HUMAN, Kv9.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96KK3
Gene
KCNS1
Ensembl
ENSG00000124134
Chromosome
20
Canonical length
526 aa
Protein class
Predicted membrane proteins, Transporters, Voltage-gated ion channels
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane
Quaternary structure
Homomultimer

OverviewNCBI Gene

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

526 residues, UniProt reviewed canonical sequence.

>Q96KK3|KCNS1
     1  MLMLLVRGTH YENLRSKVVL PTPLGGRSTE TFVSEFPGPD TGIRWRRSDE ALRVNVGGVR
    61  RQLSARALAR FPGTRLGRLQ AAASEEQARR LCDDYDEAAR EFYFDRHPGF FLSLLHFYRT
   121  GHLHVLDELC VFAFGQEADY WGLGENALAA CCRARYLERR LTQPHAWDED SDTPSSVDPC
   181  PDEISDVQRE LARYGAARCG RLRRRLWLTM ENPGYSLPSK LFSCVSISVV LASIAAMCIH
   241  SLPEYQAREA AAAVAAVAAG RSPEGVRDDP VLRRLEYFCI AWFSFEVSSR LLLAPSTRNF
   301  FCHPLNLIDI VSVLPFYLTL LAGVALGDQG GKEFGHLGKV VQVFRLMRIF RVLKLARHST
   361  GLRSLGATLK HSYREVGILL LYLAVGVSVF SGVAYTAEKE EDVGFNTIPA CWWWGTVSMT
   421  TVGYGDVVPV TVAGKLAASG CILGGILVVA LPITIIFNKF SHFYRRQKAL EAAVRNSNHQ
   481  EFEDLLSSID GVSEASLETS RETSQEGQSA DLESQAPSEP PHPQMY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 24 nTPM
  • seminal vesicle: 2.7 nTPM
  • gallbladder: 2.3 nTPM
  • salivary gland: 1.4 nTPM
  • hippocampal formation: 1.2 nTPM
  • skin: 1 nTPM

Single-cell type

  • cholangiocytes: 6.7 nCPM
  • alveolar cells type 2: 2.7 nCPM
  • brain excitatory neurons: 1.5 nCPM
  • differentiating spermatogonia: 1.4 nCPM
  • salivary myoepithelial cells: 1.3 nCPM
  • salivary acinar cells: 1.2 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 58 nTPM
  • white matter: 25 nTPM
  • basal ganglia: 12 nTPM
  • hippocampal formation: 3.6 nTPM
  • amygdala: 2.8 nTPM
  • medulla oblongata: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.11
gnomAD missense Z
1.66
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNS1 as an antibody target. Whether an autoantibody or antibody against KCNS1 could matter depends on whether native KCNS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNS1 is annotated at the cell surface, where native KCNS1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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