Seroatlas · Human Serome Atlas

KLHL13

Kelch-like protein 13

Also known as: BKLHD2, FLJ10262, KIAA1309, KLH13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2N7
Gene: KLHL13
Ensembl: ENSG00000003096
Chromosome: X
Canonical length: 655 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

655 residues, UniProt reviewed canonical sequence.

>Q9P2N7|KLHL13
     1  MPLKWKTSSP AIWKFPVPVL KTSRSTPLSP AYISLVEEED QHMKLSLGGS EMGLSSHLQS
    61  SKAGPTRIFT SNTHSSVVLQ GFDQLRLEGL LCDVTLMPGD TDDAFPVHRV MMASASDYFK
   121  AMFTGGMKEQ DLMCIKLHGV SKVGLRKIID FIYTAKLSLN MDNLQDTLEA ASFLQILPVL
   181  DFCKVFLISG VTLDNCVEVG RIANTYNLTE VDKYVNSFVL KNFPALLSTG EFLKLPFERL
   241  AFVLSSNSLK HCTELELFKA TCRWLRLEEP RMDFAAKLMK NIRFPLMTPQ ELINYVQTVD
   301  FMRTDNTCVN LLLEASNYQM MPYMQPVMQS DRTAIRSDTT HLVTLGGVLR QQLVVSKELR
   361  MYDEKAHEWK SLAPMDAPRY QHGIAVIGNF LYVVGGQSNY DTKGKTAVDT VFRFDPRYNK
   421  WMQVASLNEK RTFFHLSALK GYLYAVGGRN AAGELPTVEC YNPRTNEWTY VAKMSEPHYG
   481  HAGTVYGGVM YISGGITHDT FQKELMCFDP DTDKWIQKAP MTTVRGLHCM CTVGERLYVI
   541  GGNHFRGTSD YDDVLSCEYY SPILDQWTPI AAMLRGQSDV GVAVFENKIY VVGGYSWNNR
   601  CMVEIVQKYD PDKDEWHKVF DLPESLGGIR ACTLTVFPPE ETTPSPSRES PLSAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

endometrium: 29 nTPM
smooth muscle: 27 nTPM
breast: 23 nTPM
cervix: 19 nTPM
kidney: 15 nTPM
basal ganglia: 12 nTPM

Single-cell type

distal convoluted tubule cells: 519 nCPM
loop of henle epithelial cells: 412 nCPM
renal connecting tubule cells: 381 nCPM
breast myoepithelial cells: 213 nCPM
myosatellite cells: 181 nCPM
fibro-adipogenic progenitors: 180 nCPM

Immune cell

eosinophil: 7.3 nTPM
plasmacytoid DC: 4.1 nTPM
basophil: 2.4 nTPM
NK-cell: 1.1 nTPM
myeloid DC: 0.9 nTPM
naive CD4 T-cell: 0.6 nTPM

Brain region

basal ganglia: 23 nTPM
midbrain: 22 nTPM
pons: 14 nTPM
hypothalamus: 13 nTPM
thalamus: 13 nTPM
choroid plexus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.04
gnomAD missense Z: 2.2
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cullin family protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHL13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL13 as an antibody target. Whether an autoantibody or antibody against KLHL13 could matter depends on whether native KLHL13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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