Seroatlas · Human Serome Atlas

KLHL32

Kelch-like protein 32

Also known as: BKLHD5, KIAA1900, KLH32_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96NJ5
Gene
KLHL32
Ensembl
ENSG00000186231
Chromosome
6
Canonical length
620 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for KLHL32 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

620 residues, UniProt reviewed canonical sequence.

>Q96NJ5|KLHL32
     1  MPSERCLSIQ EMLTGQRLCH SESHNDSVLA ALNQQRSDGI LCDITLIAEE QKFHAHKAVL
    61  AACSDYFRAM FSLCMVESGA DEVNLHGVTS LGLKQALEFA YTGQILLEPG VIQDVLAAGS
   121  HLQLLELLNL CSHYLIQELN SFNYLDLYRL ADLFNLTLLE KAVIDFLVKH LSELLKSRPE
   181  EVLTLPYCLL QEVLKSDRLT SLSEEQIWQL AVRWLEHNCH YQYMDELLQY IRFGLMDVDT
   241  LHTVALSHPL VQASETATAL VNEALEYHQS IYAQPVWQTR RTKPRFQSDT LYIIGGKKRE
   301  VCKVKELRYF NPVDQENALI AAIANWSELA PMPVGRSHHC VAVMGDFLFV AGGEVEHASG
   361  RTCAVRTACR YDPRSNSWAE IAPMKNCREH FVLGAMEEYL YAVGGRNELR QVLPTVERYC
   421  PKKNKWTFVQ SFDRSLSCHA GYVADGLLWI SGGVTNTAQY QNRLMVYEPN QNKWISRSPM
   481  LQRRVYHSMA AVQRKLYVLG GNDLDYNNDR ILVRHIDSYN IDTDQWTRCN FNLLTGQNES
   541  GVAVHNGRIY LVGGYSIWTN EPLACIQVLD VSREGKEEVF YGPTLPFASN GIAACFLPAP
   601  YFTCPNLQTL QVPHHRIGTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 20 nTPM
  • hippocampal formation: 16 nTPM
  • midbrain: 15 nTPM
  • cerebral cortex: 14 nTPM
  • basal ganglia: 12 nTPM
  • hypothalamus: 11 nTPM

Single-cell type

  • oligodendrocytes: 884 nCPM
  • ependymal cells: 590 nCPM
  • bergmann glia: 408 nCPM
  • retinal horizontal cells: 403 nCPM
  • respiratory ciliated cells: 347 nCPM
  • oligodendrocyte progenitor cells: 315 nCPM

Immune cell

  • naive CD8 T-cell: 2.6 nTPM
  • naive CD4 T-cell: 1.9 nTPM
  • memory CD4 T-cell: 1.7 nTPM
  • T-reg: 1.3 nTPM
  • memory B-cell: 1 nTPM
  • MAIT T-cell: 0.9 nTPM

Brain region

  • white matter: 135 nTPM
  • basal ganglia: 87 nTPM
  • cerebral cortex: 86 nTPM
  • medulla oblongata: 70 nTPM
  • thalamus: 65 nTPM
  • pons: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.01
gnomAD missense Z
2.03
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL32 as an antibody target. Whether an autoantibody or antibody against KLHL32 could matter depends on whether native KLHL32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHL32. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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