Seroatlas · Human Serome Atlas

MYNN

Myoneurin

Also known as: MYNN_HUMAN, SBBIZ1, ZBTB31, ZNF902

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPC7
Gene: MYNN
Ensembl: ENSG00000085274
Chromosome: 3
Canonical length: 610 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

610 residues, UniProt reviewed canonical sequence.

>Q9NPC7|MYNN
     1  MQYSHHCEHL LERLNKQREA GFLCDCTIVI GEFQFKAHRN VLASFSEYFG AIYRSTSENN
    61  VFLDQSQVKA DGFQKLLEFI YTGTLNLDSW NVKEIHQAAD YLKVEEVVTK CKIKMEDFAF
   121  IANPSSTEIS SITGNIELNQ QTCLLTLRDY NNREKSEVST DLIQANPKQG ALAKKSSQTK
   181  KKKKAFNSPK TGQNKTVQYP SDILENASVE LFLDANKLPT PVVEQVAQIN DNSELELTSV
   241  VENTFPAQDI VHTVTVKRKR GKSQPNCALK EHSMSNIASV KSPYEAENSG EELDQRYSKA
   301  KPMCNTCGKV FSEASSLRRH MRIHKGVKPY VCHLCGKAFT QCNQLKTHVR THTGEKPYKC
   361  ELCDKGFAQK CQLVFHSRMH HGEEKPYKCD VCNLQFATSS NLKIHARKHS GEKPYVCDRC
   421  GQRFAQASTL TYHVRRHTGE KPYVCDTCGK AFAVSSSLIT HSRKHTGEKP YICGICGKSF
   481  ISSGELNKHF RSHTGERPFI CELCGNSYTD IKNLKKHKTK VHSGADKTLD SSAEDHTLSE
   541  QDSIQKSPLS ETMDVKPSDM TLPLALPLGT EDHHMLLPVT DTQSPTSDTL LRSTVNGYSE
   601  PQLIFLQQLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYNN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

retina: 14 nTPM
bone marrow: 14 nTPM
tongue: 10 nTPM
endometrium: 9.6 nTPM
testis: 9.2 nTPM
tonsil: 9.2 nTPM

Single-cell type

late primary spermatocytes: 62 nCPM
rod photoreceptor cells: 62 nCPM
neutrophils: 55 nCPM
early spermatids: 47 nCPM
basal keratinocytes: 46 nCPM
suprabasal keratinocytes: 42 nCPM

Immune cell

basophil: 22 nTPM
eosinophil: 11 nTPM
NK-cell: 11 nTPM
naive CD4 T-cell: 10 nTPM
MAIT T-cell: 10 nTPM
T-reg: 9.1 nTPM

Brain region

cerebellum: 16 nTPM
white matter: 12 nTPM
cerebral cortex: 11 nTPM
choroid plexus: 11 nTPM
basal ganglia: 9.8 nTPM
midbrain: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.57
gnomAD missense Z: 1.51
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYNN as an antibody target. Whether an autoantibody or antibody against MYNN could matter depends on whether native MYNN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYNN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYNN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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