Seroatlas · Human Serome Atlas

BTBD19

BTB/POZ domain-containing protein 19

Also known as: BTBDJ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9JJ37
Gene
BTBD19
Ensembl
ENSG00000222009
Chromosome
1
Canonical length
291 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

No narrative summary is available for BTBD19 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

291 residues, UniProt reviewed canonical sequence.

>C9JJ37|BTBD19
     1  MEPLGLVVHG KAEPFSAALR SLVNNPRYSD VCFVVGQERQ EVFAHRCLLA CRCNFFQRLL
    61  GTEPGPGVPS PVVLSTVPTE AFLAVLEFLY TNSVKLYRHS VLEVLTAAVE YGLEELRELC
   121  LQFVVKVLDV DLVCEALQVA VTFGLGQLQE RCVAFIEAHS QEALRTRGFL ELSAAALLPL
   181  LRSDKLCVDE AELVRAARSW ARVGAAVLER PVAEVAAPVV KELRLALLAP AELSALEEQN
   241  RQEPLIPVEQ IVEAWKCHAL RRGDEARGAP CRRRRGTLPR EHHRFLDLSF K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTBD19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
9.3 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 9.3 nTPM
  • endometrium: 7.3 nTPM
  • adrenal gland: 4.9 nTPM
  • pituitary gland: 4.7 nTPM
  • gallbladder: 4.4 nTPM
  • smooth muscle: 4 nTPM

Single-cell type

  • neutrophils: 200 nCPM
  • epicardial cells: 43 nCPM
  • monocytes: 40 nCPM
  • adrenal cortex cells: 35 nCPM
  • choroid plexus epithelial cells: 32 nCPM
  • endometrial glandular cells: 31 nCPM

Immune cell

  • neutrophil: 0.8 nTPM
  • myeloid DC: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • choroid plexus: 28 nTPM
  • medulla oblongata: 13 nTPM
  • hypothalamus: 9.1 nTPM
  • midbrain: 8.9 nTPM
  • pons: 8.7 nTPM
  • thalamus: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.05
gnomAD missense Z
1.78

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTBD19 as an antibody target. Whether an autoantibody or antibody against BTBD19 could matter depends on whether native BTBD19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTBD19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BTBD19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BTBD19. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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