ZBTB4
Zinc finger and BTB domain-containing protein 4
Also known as: KAISO-L1, KIAA1538, ZBTB4_HUMAN, ZNF903
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9P1Z0
- Gene
- ZBTB4
- Ensembl
- ENSG00000174282
- Chromosome
- 17
- Canonical length
- 1013 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nuclear bodies,Cytosol
OverviewNCBI Gene
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleotide binding activity; and protein homodimerization activity. Involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
1013 residues, UniProt reviewed canonical sequence.
>Q9P1Z0|ZBTB4
1 MPPPAEVTDP SHAPAVLRQL NEQRLRGLFC DVTLIAGDTK FPAHRSVLAA SSPFFREALL
61 TSAPLPLPPA TGGAAPNPAT TTAASSSSSS SSSSSSSSSS ASSSSSSSSS SPPPASPPAS
121 SPPRVLELPG VPAAAFSDVL NFIYSARLAL PGGGGDGAAV AEIGALGRRL GISRLQGLGE
181 GGDAWVPPTP APMATSQPEE DSFGPGPRPA GEWEGDRAEA QAPDLQCSLP RRPLPCPQCG
241 KSFIHPKRLQ THEAQCRRGA STRGSTGLGA GGAGPGGPAG VDASALPPPV GFRGGPEHVV
301 KVVGGHVLYV CAACERSYVT LSSLKRHSNV HSWRRKYPCR YCEKVFALAE YRTKHEVWHT
361 GERRYQCIFC WETFVTYYNL KTHQRAFHGI SPGLLASEKT PNGGYKPKLN TLKLYRLLPM
421 RAAKRPYKTY SQGAPEAPLS PTLNTPAPVA MPASPPPGPP PAPEPGPPPS VITFAHPAPS
481 VIVHGGSSSG GGGSGTASTG GSQAASVITY TAPPRPPKKR EYPPPPPEPA ATPTSPATAV
541 SPATAAGPAM ATTTEEAKGR NPRAGRTLTY TAKPVGGIGG GGGPPTGAGR GPSQLQAPPP
601 LCQITVRIGE EAIVKRRISE TDLRPGELSG EEMEESEEDE EEEDEEEEEE DEEESKAGGE
661 DQLWRPYYSY KPKRKAGAAG GASVGGSGLP RGRRPPRWRQ KLERRSWEET PAAESPAGRA
721 RTERRHRCGD CAQTFTTLRK LRKHQEAHGG GSHSSRAGRR PSTRFTCPHC AKVCKTAAAL
781 SRHGQRHAAE RPGGTPTPVI AYSKGSAGTR PGDVKEEAPQ EMQVSSSSGE AGGGSTAAEE
841 ASETASLQDP IISGGEEPPV VASGGSYVYP PVQEFPLALI GGGREPGGGR GKSGSEGPVG
901 AGEGDRMEGI GAAKVTFYPE PYPLVYGPQL LAAYPYNFSN LAALPVALNM VLPDEKGAGA
961 LPFLPGVFGY AVNPQAAPPA PPTPPPPTLP PPIPPKGEGE RAGVERTQKG DVGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZBTB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 51 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 51 nTPM
- cerebellum: 47 nTPM
- ovary: 46 nTPM
- cerebral cortex: 45 nTPM
- colon: 44 nTPM
- urinary bladder: 44 nTPM
Single-cell type
- choroid plexus epithelial cells: 112 nCPM
- podocytes: 94 nCPM
- renal collecting duct intercalated cells: 84 nCPM
- renal collecting duct principal cells: 59 nCPM
- renal connecting tubule cells: 58 nCPM
- astrocytes: 57 nCPM
Immune cell
- non-classical monocyte: 1.7 nTPM
- gdT-cell: 1 nTPM
- MAIT T-cell: 1 nTPM
- naive CD4 T-cell: 1 nTPM
- naive CD8 T-cell: 1 nTPM
- memory CD4 T-cell: 0.8 nTPM
Brain region
- pons: 68 nTPM
- medulla oblongata: 62 nTPM
- thalamus: 62 nTPM
- cerebral cortex: 59 nTPM
- midbrain: 58 nTPM
- amygdala: 57 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.11
- gnomAD pLI
- 1
- gnomAD missense Z
- 1.93
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- DNA damage response
- negative regulation of DNA-templated transcription
- negative regulation of transcription by RNA polymerase II
- regulation of DNA-templated transcription
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- methyl-CpG binding
- protein homodimerization activity
- protein kinase binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- zinc ion binding
- methyl-CpNpG binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZBTB4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZBTB4 as an antibody target. Whether an autoantibody or antibody against ZBTB4 could matter depends on whether native ZBTB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZBTB4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZBTB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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