Seroatlas · Human Serome Atlas

BTBD10

BTB/POZ domain-containing protein 10

Also known as: BTBDA_HUMAN, GMRP-1, GMRP1, MGC13007

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSF8
Gene
BTBD10
Ensembl
ENSG00000148925
Chromosome
11
Canonical length
475 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to be involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and type B pancreatic cell proliferation. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q9BSF8|BTBD10
     1  MAGRPHPYDG NSSDPENWDR KLHSRPRKLY KHSSTSSRIA KGGVDHTKMS LHGASGGHER
    61  SRDRRRSSDR SRDSSHERTE SQLTPCIRNV TSPTRQHHVE REKDHSSSRP SSPRPQKASP
   121  NGSISSAGNS SRNSSQSSSD GSCKTAGEMV FVYENAKEGA RNIRTSERVT LIVDNTRFVV
   181  DPSIFTAQPN TMLGRMFGSG REHNFTRPNE KGEYEVAEGI GSTVFRAILD YYKTGIIRCP
   241  DGISIPELRE ACDYLCISFE YSTIKCRDLS ALMHELSNDG ARRQFEFYLE EMILPLMVAS
   301  AQSGERECHI VVLTDDDVVD WDEEYPPQMG EEYSQIIYST KLYRFFKYIE NRDVAKSVLK
   361  ERGLKKIRLG IEGYPTYKEK VKKRPGGRPE VIYNYVQRPF IRMSWEKEEG KSRHVDFQCV
   421  KSKSITNLAA AAADIPQDQL VVMHPTPQVD ELDILPIHPP SGNSDLDPDA QNPML

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTBD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 36 nTPM
  • testis: 36 nTPM
  • basal ganglia: 36 nTPM
  • esophagus: 27 nTPM
  • urinary bladder: 25 nTPM
  • blood vessel: 20 nTPM

Single-cell type

  • neutrophil progenitors: 205 nCPM
  • late primary spermatocytes: 193 nCPM
  • esophageal apical cells: 179 nCPM
  • neutrophils: 173 nCPM
  • early primary spermatocytes: 166 nCPM
  • thyrotrophs: 149 nCPM

Immune cell

  • neutrophil: 65 nTPM
  • non-classical monocyte: 51 nTPM
  • basophil: 41 nTPM
  • intermediate monocyte: 40 nTPM
  • eosinophil: 38 nTPM
  • myeloid DC: 29 nTPM

Brain region

  • basal ganglia: 85 nTPM
  • cerebral cortex: 78 nTPM
  • white matter: 65 nTPM
  • hypothalamus: 60 nTPM
  • cerebellum: 60 nTPM
  • hippocampal formation: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0
gnomAD missense Z
2.65
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BTBD10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTBD10 as an antibody target. Whether an autoantibody or antibody against BTBD10 could matter depends on whether native BTBD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTBD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BTBD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BTBD10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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