KLHL38
Kelch-like protein 38
Also known as: C8ORFK36, KLH38_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q2WGJ6
- Gene
- KLHL38
- Ensembl
- ENSG00000175946
- Chromosome
- 8
- Canonical length
- 581 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
581 residues, UniProt reviewed canonical sequence.
>Q2WGJ6|KLHL38
1 MDEESLDGLL FKDHDFSSDL LRQLNSLRQS RILTDVSICA GAREIPCHRN VLASSSPYFR
61 AMFCSSFREK SEAKVQLKGI DPPTLDQIVS YVYTGEAHIA TDNVLPVMEA ASMLQFPKLF
121 EACSSYLQSQ LAPSNCLGMI RLSEILSCET LKKKAREVAL TSFPEVAASA DLKELCALEL
181 RDYLGDDGLC GEEEKVFEAL MVWIKHDLQA RKRYMQELFK QVRLQYIHPA FFHHFIANDA
241 LLQSSPACQI ILETAKRQMF SLCGTTVPDC KLLLHVPPRN SYQDFLILLG GRKDSQQTTR
301 DVLLYSKQTG QWQSLAKLPT RLYKASAITL HRSIYVLGGM AVSSGRSLVS HNVYIFSLKL
361 NQWRLGEPML VARYSHRSTA HKNFIFSIGG IGEGQELMGS MERYDSICNV WESMASMPVG
421 VLHPAVAVKD QRLYLFGGED IMQNPVRLIQ VYHISRNSWF KMETRMIKNV CAPAVVLGER
481 IVIVGGYTRR ILAYDPQSNK FVKCADMKDR RMHHGATVMG NKLYVTGGRR LTTDCNIEDS
541 ASFDCYDPET DTWTSQGQLP HKLFDHACLT LQCIPRTSGL PLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KLHL38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 238 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 238 nTPM
- tongue: 66 nTPM
- heart muscle: 51 nTPM
- smooth muscle: 2.3 nTPM
- esophagus: 2 nTPM
- placenta: 1.4 nTPM
Single-cell type
- cardiomyocytes: 44 nCPM
- myonuclei: 26 nCPM
- thymic myoid cells: 22 nCPM
- vascular smooth muscle cells: 1.8 nCPM
- adipocytes: 1.6 nCPM
- respiratory ciliated cells: 1.3 nCPM
Immune cell
- basophil: 0.8 nTPM
- classical monocyte: 0.1 nTPM
- naive B-cell: 0.1 nTPM
- neutrophil: 0.1 nTPM
- NK-cell: 0.1 nTPM
- plasmacytoid DC: 0.1 nTPM
Brain region
- cerebral cortex: 3.6 nTPM
- amygdala: 2.5 nTPM
- white matter: 2.4 nTPM
- basal ganglia: 2.1 nTPM
- cerebellum: 2 nTPM
- hypothalamus: 2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.25
- gnomAD pLI
- 0
- gnomAD missense Z
- -1.23
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KLHL38 as an antibody target. Whether an autoantibody or antibody against KLHL38 could matter depends on whether native KLHL38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KLHL38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KLHL38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...