Seroatlas · Human Serome Atlas

KCTD20

BTB/POZ domain-containing protein KCTD20

Also known as: C6orf69, dJ108K11.3, KCD20_HUMAN, MGC14254

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5Y7
Gene: KCTD20
Ensembl: ENSG00000112078
Chromosome: 6
Canonical length: 419 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Endoplasmic reticulum

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Predicted to be involved in positive regulation of phosphorylation. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q7Z5Y7|KCTD20
     1  MNVHRGSDSD RLLRQEASCL VDDTLAVAQE KEANSLASSG PHNLTYPLGP RNEDLSLDYA
    61  SQPANLQFPH IMPLAEDIKG SCFQSGNKRN HEPFIAPERF GNSSVGFGSN SHSQAPEKVT
   121  LLVDGTRFVV NPQIFTAHPD TMLGRMFGPG REYNFTRPNE KGEYEIAEGI SATVFRTVLD
   181  YYKTGIINCP DGISIPDLRD TCDYLCINFD FNTIRCQDLS ALLHELSNDG AHKQFDHYLE
   241  ELILPIMVGC AKKGERECHI VVLTDEDSVD WDEDHPPPMG EEYSQILYSS KLYRFFKYIE
   301  NRDVAKTVLK ERGLKNIRIG IEGYPTCKEK IKRRPGGRSE VIYNYVQRPF IQMSWEKEEG
   361  KSRHVDFQCV RSKSLTNLVA AGDDVLEDQE ILMHHPPQVD ELDRLNAPLS QMASNDFQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 39 nTPM
thymus: 32 nTPM
smooth muscle: 30 nTPM
liver: 29 nTPM
skin: 28 nTPM
tonsil: 28 nTPM

Single-cell type

platelets: 540 nCPM
neutrophils: 376 nCPM
monocytes: 256 nCPM
esophageal apical cells: 196 nCPM
mast cells: 126 nCPM
cdc: 126 nCPM

Immune cell

basophil: 30 nTPM
classical monocyte: 17 nTPM
myeloid DC: 16 nTPM
intermediate monocyte: 15 nTPM
total PBMC: 14 nTPM
neutrophil: 13 nTPM

Brain region

hypothalamus: 41 nTPM
midbrain: 40 nTPM
medulla oblongata: 39 nTPM
pons: 39 nTPM
thalamus: 36 nTPM
white matter: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 1.19
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cytoplasm

InteractionsUniProt · HPA

Protein binding partners of KCTD20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD20 as an antibody target. Whether an autoantibody or antibody against KCTD20 could matter depends on whether native KCTD20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCTD20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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