Seroatlas · Human Serome Atlas

KLHL26

Kelch-like protein 26

Also known as: KLH26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53HC5
Gene: KLHL26
Ensembl: ENSG00000167487
Chromosome: 19
Canonical length: 615 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for KLHL26 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

615 residues, UniProt reviewed canonical sequence.

>Q53HC5|KLHL26
     1  MAESGGSSGG AGGGGAFGAG PGPERPNSTA DKNGALKCTF SAPSHSTSLL QGLATLRAQG
    61  QLLDVVLTIN REAFPAHKVV LAACSDYFRA MFTGGMREAS QDVIELKGVS ARGLRHIIDF
   121  AYSAEVTLDL DCVQDVLGAA VFLQMLPVVE LCEEFLKAAM SVETCLNIGQ MATTFSLASL
   181  RESVDAFTFR HFLQIAEEED FLRLPLERLV FFLQSNRLQS CAEIDLFRAA VRWLQHDPAR
   241  RPRASHVLCH IRFPLMQSSE LVDSVQTLDI MVEDVLCRQY LLEAFNYQVL PFRQHEMQSP
   301  RTAVRSDVPS LVTFGGTPYT DSDRSVSSKV YQLPEPGARH FRELTEMEVG CSHTCVAVLD
   361  NFVYVAGGQH LQYRSGEGAV DACYRYDPHL NRWLRLQAMQ ESRIQFQLNV LCGMVYATGG
   421  RNRAGSLASV ERYCPRRNEW GYACSLKRRT WGHAGAASGG RLYISGGYGI SVEDKKALHC
   481  YDPVADQWEF KAPMSEPRVL HAMVGAGGRI YALGGRMDHV DRCFDVLAVE YYVPETDQWT
   541  SVSPMRAGQS EAGCCLLERK IYIVGGYNWR LNNVTGIVQV YNTDTDEWER DLHFPESFAG
   601  IACAPVLLPR AGTRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 25 nTPM
cerebral cortex: 14 nTPM
basal ganglia: 12 nTPM
cerebellum: 11 nTPM
amygdala: 8.9 nTPM
hippocampal formation: 8.4 nTPM

Single-cell type

hepatic stellate cells: 19 nCPM
müller glia: 15 nCPM
vascular smooth muscle cells: 15 nCPM
oocytes: 14 nCPM
ependymal cells: 13 nCPM
astrocytes: 13 nCPM

Immune cell

NK-cell: 4.4 nTPM
MAIT T-cell: 2.4 nTPM
memory CD8 T-cell: 1.8 nTPM
classical monocyte: 1.5 nTPM
gdT-cell: 1.5 nTPM
memory CD4 T-cell: 1.5 nTPM

Brain region

cerebral cortex: 30 nTPM
basal ganglia: 30 nTPM
hippocampal formation: 28 nTPM
amygdala: 27 nTPM
hypothalamus: 25 nTPM
white matter: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 1.31
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHL26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KLHL20

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL26 as an antibody target. Whether an autoantibody or antibody against KLHL26 could matter depends on whether native KLHL26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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