Seroatlas · Human Serome Atlas

KLHL4

Kelch-like protein 4

Also known as: DKELCHL, KHL4, KIAA1687, KLHL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C0H6
Gene
KLHL4
Ensembl
ENSG00000102271
Chromosome
X
Canonical length
718 aa
Protein class
Predicted intracellular proteins
Subcellular location
Microtubules,Primary cilium,Centriolar satellite,Basal body

OverviewNCBI Gene

This gene encodes a member of the kelch family of proteins, which are characterized by kelch repeat motifs and a POZ/BTB protein-binding domain. It is thought that kelch repeats are actin binding domains. However, the specific function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

718 residues, UniProt reviewed canonical sequence.

>Q9C0H6|KLHL4
     1  MSVSGKKEFD VKQILRLRWR WFSHPFQGST NTGSCLQQEG YEHRGTPVQG RLKSHSRDRN
    61  GLKKSNSPVH HNILAPVPGP APAHQRAVQN LQQHNLIVHF QANEDTPKSV PEKNLFKEAC
   121  EKRAQDLEMM ADDNIEDSTA RLDTQHSEDM NATRSEEQFH VINHAEQTLR KMENYLKEKQ
   181  LCDVLLIAGH LRIPAHRLVL SAVSDYFAAM FTNDVLEAKQ EEVRMEGVDP NALNSLVQYA
   241  YTGVLQLKED TIESLLAAAC LLQLTQVIDV CSNFLIKQLH PSNCLGIRSF GDAQGCTELL
   301  NVAHKYTMEH FIEVIKNQEF LLLPANEISK LLCSDDINVP DEETIFHALM QWVGHDVQNR
   361  QGELGMLLSY IRLPLLPPQL LADLETSSMF TGDLECQKLL MEAMKYHLLP ERRSMMQSPR
   421  TKPRKSTVGA LYAVGGMDAM KGTTTIEKYD LRTNSWLHIG TMNGRRLQFG VAVIDNKLYV
   481  VGGRDGLKTL NTVECFNPVG KIWTVMPPMS THRHGLGVAT LEGPMYAVGG HDGWSYLNTV
   541  ERWDPEGRQW NYVASMSTPR STVGVVALNN KLYAIGGRDG SSCLKSMEYF DPHTNKWSLC
   601  APMSKRRGGV GVATYNGFLY VVGGHDAPAS NHCSRLSDCV ERYDPKGDSW STVAPLSVPR
   661  DAVAVCPLGD KLYVVGGYDG HTYLNTVESY DAQRNEWKEE VPVNIGRAGA CVVVVKLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 23 nTPM
  • ovary: 9.6 nTPM
  • spinal cord: 9.6 nTPM
  • testis: 6.5 nTPM
  • cerebral cortex: 5.5 nTPM
  • midbrain: 5.2 nTPM

Single-cell type

  • sertoli cells: 406 nCPM
  • adrenal cortex cells: 367 nCPM
  • oligodendrocytes: 326 nCPM
  • lymphatic endothelial cells: 235 nCPM
  • mesothelial cells: 105 nCPM
  • cone photoreceptor cells: 93 nCPM

Immune cell

  • T-reg: 0.2 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • white matter: 44 nTPM
  • basal ganglia: 22 nTPM
  • medulla oblongata: 21 nTPM
  • midbrain: 16 nTPM
  • pons: 16 nTPM
  • spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.66
gnomAD missense Z
0.89
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL4 as an antibody target. Whether an autoantibody or antibody against KLHL4 could matter depends on whether native KLHL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHL4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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