Seroatlas · Human Serome Atlas

KCTD6

BTB/POZ domain-containing protein KCTD6

Also known as: KCASH3, KCTD6_HUMAN, MGC27385

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NC69
Gene: KCTD6
Ensembl: ENSG00000168301
Chromosome: 3
Canonical length: 237 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Mitochondria
Quaternary structure: Homopentamer

OverviewNCBI Gene

Enables ankyrin binding activity; cullin family protein binding activity; and identical protein binding activity. Involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>Q8NC69|KCTD6
     1  MDNGDWGYMM TDPVTLNVGG HLYTTSLTTL TRYPDSMLGA MFGGDFPTAR DPQGNYFIDR
    61  DGPLFRYVLN FLRTSELTLP LDFKEFDLLR KEADFYQIEP LIQCLNDPKP LYPMDTFEEV
   121  VELSSTRKLS KYSNPVAVII TQLTITTKVH SLLEGISNYF TKWNKHMMDT RDCQVSFTFG
   181  PCDYHQEVSL RVHLMEYITK QGFTIRNTRV HHMSERANEN TVEHNWTFCR LARKTDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 48 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 48 nTPM
retina: 42 nTPM
epididymis: 29 nTPM
choroid plexus: 23 nTPM
cerebral cortex: 22 nTPM
hippocampal formation: 21 nTPM

Single-cell type

astrocytes: 39 nCPM
choroid plexus epithelial cells: 35 nCPM
granulosa cells: 30 nCPM
retinal pigment epithelial cells: 30 nCPM
retinal amacrine cells: 29 nCPM
medullary thymic epithelial cells: 26 nCPM

Immune cell

basophil: 26 nTPM
myeloid DC: 23 nTPM
intermediate monocyte: 17 nTPM
MAIT T-cell: 17 nTPM
classical monocyte: 16 nTPM
gdT-cell: 15 nTPM

Brain region

white matter: 54 nTPM
cerebellum: 53 nTPM
hippocampal formation: 46 nTPM
cerebral cortex: 42 nTPM
choroid plexus: 42 nTPM
midbrain: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0.02
gnomAD missense Z: 2.13
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCTD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD6 as an antibody target. Whether an autoantibody or antibody against KCTD6 could matter depends on whether native KCTD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCTD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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