Seroatlas · Human Serome Atlas

ZBTB43

Zinc finger and BTB domain-containing protein 43

Also known as: FLJ22470, KIAA0414, ZBT43_HUMAN, ZBTB22B, ZNF-X, ZNF297B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43298
Gene: ZBTB43
Ensembl: ENSG00000169155
Chromosome: 9
Canonical length: 467 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables RNA polymerase III general transcription initiation factor binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>O43298|ZBTB43
     1  MEPGTNSFRV EFPDFSSTIL QKLNQQRQQG QLCDVSIVVQ GHIFRAHKAV LAASSPYFCD
    61  QVLLKNSRRI VLPDVMNPRV FENILLSSYT GRLVMPAPEI VSYLTAASFL QMWHVVDKCT
   121  EVLEGNPTVL CQKLNHGSDH QSPSSSSYNG LVESFELGSG GHTDFPKAQE LRDGENEEES
   181  TKDELSSQLT EHEYLPSNSS TEHDRLSTEM ASQDGEEGAS DSAEFHYTRP MYSKPSIMAH
   241  KRWIHVKPER LEQACEGMDV HATYDEHQVT ESINTVQTEH TVQPSGVEED FHIGEKKVEA
   301  EFDEQADESN YDEQVDFYGS SMEEFSGERS DGNLIGHRQE AALAAGYSEN IEMVTGIKEE
   361  ASHLGFSATD KLYPCQCGKS FTHKSQRDRH MSMHLGLRPY GCGVCGKKFK MKHHLVGHMK
   421  IHTGIKPYEC NICAKRFMWR DSFHRHVTSC TKSYEAAKAE QNTTEAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 57 nTPM
skeletal muscle: 31 nTPM
tongue: 19 nTPM
testis: 15 nTPM
skin: 14 nTPM
heart muscle: 9.9 nTPM

Single-cell type

endometrial glandular cells: 247 nCPM
ocular epithelial cells: 227 nCPM
esophageal apical cells: 191 nCPM
epididymal basal cells: 170 nCPM
urothelial cells: 164 nCPM
suprabasal keratinocytes: 159 nCPM

Immune cell

basophil: 12 nTPM
gdT-cell: 7.1 nTPM
MAIT T-cell: 6.8 nTPM
NK-cell: 6.8 nTPM
T-reg: 6.1 nTPM
naive CD8 T-cell: 4.8 nTPM

Brain region

choroid plexus: 27 nTPM
cerebral cortex: 21 nTPM
cerebellum: 20 nTPM
white matter: 20 nTPM
basal ganglia: 18 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 0.99
gnomAD missense Z: 2.54
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II cis-regulatory region sequence-specific DNA binding
sequence-specific double-stranded DNA binding
zinc ion binding
RNA polymerase III general transcription initiation factor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB43 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB43 as an antibody target. Whether an autoantibody or antibody against ZBTB43 could matter depends on whether native ZBTB43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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