Seroatlas · Human Serome Atlas

TNFAIP1

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

Also known as: B12, B61, BACD2_HUMAN, BTBD34, EDP1, MGC2317

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13829
Gene: TNFAIP1
Ensembl: ENSG00000109079
Chromosome: 17
Canonical length: 316 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q13829|TNFAIP1
     1  MSGDTCLCPA SGAKPKLSGF KGGGLGNKYV QLNVGGSLYY TTVRALTRHD TMLKAMFSGR
    61  MEVLTDKEGW ILIDRCGKHF GTILNYLRDD TITLPQNRQE IKELMAEAKY YLIQGLVNMC
   121  QSALQDKKDS YQPVCNIPII TSLKEEERLI ESSTKPVVKL LYNRSNNKYS YTSNSDDHLL
   181  KNIELFDKLS LRFNGRVLFI KDVIGDEICC WSFYGQGRKL AEVCCTSIVY ATEKKQTKVE
   241  FPEARIYEET LNVLLYETPR VPDNSLLEAT SRSRSQASPS EDEETFELRD RVRRIHVKRY
   301  STYDDRQLGH QSTHRD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFAIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

liver: 47 nTPM
spleen: 47 nTPM
heart muscle: 42 nTPM
placenta: 42 nTPM
lung: 38 nTPM
esophagus: 37 nTPM

Single-cell type

esophageal apical cells: 100 nCPM
syncytiotrophoblasts: 93 nCPM
vascular endothelial cells: 79 nCPM
lymphatic endothelial cells: 78 nCPM
esophageal suprabasal cells: 72 nCPM
alveolar cells type 1: 66 nCPM

Immune cell

eosinophil: 9.5 nTPM
myeloid DC: 9.3 nTPM
NK-cell: 9.2 nTPM
non-classical monocyte: 8.7 nTPM
MAIT T-cell: 7.8 nTPM
classical monocyte: 7.2 nTPM

Brain region

choroid plexus: 59 nTPM
thalamus: 54 nTPM
amygdala: 46 nTPM
cerebral cortex: 45 nTPM
medulla oblongata: 42 nTPM
midbrain: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.14
gnomAD missense Z: 1.53
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNFAIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFAIP1 as an antibody target. Whether an autoantibody or antibody against TNFAIP1 could matter depends on whether native TNFAIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFAIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNFAIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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