Seroatlas · Human Serome Atlas

ABTB2

Ankyrin repeat and BTB/POZ domain-containing protein 2

Also known as: ABTB2_HUMAN, ABTB2A, BTBD22, DKFZP586C1619

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N961
Gene: ABTB2
Ensembl: ENSG00000166016
Chromosome: 11
Canonical length: 1025 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable protein heterodimerization activity. Predicted to act upstream of or within cellular response to toxic substance. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1025 residues, UniProt reviewed canonical sequence.

>Q8N961|ABTB2
     1  MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAQQHR GAAWWCYSGS
    61  MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT EGDVARVLRK GAGGRRLPQF
   121  SAEAVRRLAG LLRRALIRVA REAQRLSVLH AKCTRFEVQS AVRLVHSWAL AESCALAAVK
   181  ALSLYSMSAG DGLRRGKSAR CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE
   241  EIRARVMASH SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
   301  AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA MHHMQGRHPL
   361  CPGASPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME NPNLDPPRMT LNNERPFMLL
   421  PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA ARLLLPGLDC EPRQLKPEHC FSSFRRLDAR
   481  AATEKFNQDL GFRMLNCGRT DLINQAIEAL GPDGVNTMDD QGMTPLMYAC AAGDEAMVQM
   541  LIDAGANLDI QVPSNSPRHP SIHPDSRHWT SLTFAVLHGH ISVVQLLLDA GAHVEGSAVN
   601  GGEDSYAETP LQLASAAGNY ELVSLLLSRG ADPLLSMLEA HGMGSSLHED MNCFSHSAAH
   661  GHRNVLRKLL TQPQQAKADV LSLEEILAEG VEESDASSQG SGSEGPVRLS RTRTKALQEA
   721  MYYSAEHGYV DITMELRALG VPWKLHIWIE SLRTSFSQSR YSVVQSLLRD FSSIREEEYN
   781  EELVTEGLQL MFDILKTSKN DSVIQQLATI FTHCYGSSPI PSIPEIRKTL PARLDPHFLN
   841  NKEMSDVTFL VEGKLFYAHK VLLVTASNRF KTLMTNKSEQ DGDSSKTIEI SDMKYHIFQM
   901  MMQYLYYGGT ESMEIPTTDI LELLSAASLF QLDALQRHCE ILCSQTLSME SAVNTYKYAK
   961  IHNAPELALF CEGFFLKHMK ALLEQDAFRQ LIYGRSSKVQ GLDPLQDLQN TLAERVHSVY
  1021  ITSRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABTB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 22 nTPM
skeletal muscle: 16 nTPM
adrenal gland: 14 nTPM
heart muscle: 12 nTPM
liver: 11 nTPM
kidney: 9.2 nTPM

Single-cell type

renal collecting duct principal cells: 1,083 nCPM
renal connecting tubule cells: 1,049 nCPM
syncytiotrophoblasts: 504 nCPM
endometrial glandular cells: 435 nCPM
urothelial cells: 432 nCPM
distal convoluted tubule cells: 376 nCPM

Immune cell

eosinophil: 5 nTPM
plasmacytoid DC: 1.6 nTPM
intermediate monocyte: 0.2 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0.1 nTPM
myeloid DC: 0.1 nTPM

Brain region

medulla oblongata: 54 nTPM
white matter: 44 nTPM
cerebellum: 41 nTPM
pons: 37 nTPM
midbrain: 36 nTPM
thalamus: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0
gnomAD missense Z: 1.23
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cellular response to toxic substance

Molecular functions

protein heterodimerization activity

Protein domainsUniProt · Pfam · InterPro

BTB/POZ domain
Ankyrin repeat
Histone-fold
SKP1/BTB/POZ domain superfamily
Ankyrin repeat-containing domain superfamily
Ankyrin repeat and BTB/POZ domain-containing protein
ABTB2/3, histone-like domain
Ankyrin repeat
BTB/POZ domain
Ankyrin repeats (3 copies)
Histone domain in ABTB family protein
Ankyrin repeat and BTB/POZ domain-containing protein 2, BTB/POZ domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABTB2 as an antibody target. Whether an autoantibody or antibody against ABTB2 could matter depends on whether native ABTB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABTB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABTB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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