Seroatlas · Human Serome Atlas

BCL6B

B-cell CLL/lymphoma 6 member B protein

Also known as: BAZF, BCL6B_HUMAN, ZBTB28, ZNF62

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N143
Gene: BCL6B
Ensembl: ENSG00000161940
Chromosome: 17
Canonical length: 479 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including regulation of gene expression; regulation of inflammatory response; and type 2 immune response. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q8N143|BCL6B
     1  MGSPAAPEGA LGYVREFTRH SSDVLGNLNE LRLRGILTDV TLLVGGQPLR AHKAVLIACS
    61  GFFYSIFRGR AGVGVDVLSL PGGPEARGFA PLLDFMYTSR LRLSPATAPA VLAAATYLQM
   121  EHVVQACHRF IQASYEPLGI SLRPLEAEPP TPPTAPPPGS PRRSEGHPDP PTESRSCSQG
   181  PPSPASPDPK ACNWKKYKYI VLNSQASQAG SLVGERSSGQ PCPQARLPSG DEASSSSSSS
   241  SSSSEEGPIP GPQSRLSPTA ATVQFKCGAP ASTPYLLTSQ AQDTSGSPSE RARPLPGSEF
   301  FSCQNCEAVA GCSSGLDSLV PGDEDKPYKC QLCRSSFRYK GNLASHRTVH TGEKPYHCSI
   361  CGARFNRPAN LKTHSRIHSG EKPYKCETCG SRFVQVAHLR AHVLIHTGEK PYPCPTCGTR
   421  FRHLQTLKSH VRIHTGEKPY HCDPCGLHFR HKSQLRLHLR QKHGAATNTK VHYHILGGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL6B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 28 nTPM
lung: 28 nTPM
heart muscle: 24 nTPM
placenta: 19 nTPM
breast: 15 nTPM
tongue: 14 nTPM

Single-cell type

vascular endothelial cells: 40 nCPM
lymphatic endothelial cells: 29 nCPM
platelets: 2.8 nCPM
thymic myoid cells: 1.4 nCPM
salivary myoepithelial cells: 1.3 nCPM
undifferentiated spermatogonia: 1.3 nCPM

Immune cell

naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

thalamus: 13 nTPM
amygdala: 9.4 nTPM
medulla oblongata: 8.2 nTPM
cerebral cortex: 8 nTPM
pons: 7.9 nTPM
midbrain: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.05
gnomAD missense Z: 0.96
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCL6B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

BCL6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCL6B as an antibody target. Whether an autoantibody or antibody against BCL6B could matter depends on whether native BCL6B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCL6B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCL6B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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