Seroatlas · Human Serome Atlas

KBTBD8

Kelch repeat and BTB domain-containing protein 8

Also known as: KBTB8_HUMAN, KIAA1842, TA-KRP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NFY9
Gene
KBTBD8
Ensembl
ENSG00000163376
Chromosome
3
Canonical length
601 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in neural crest cell development; neural crest formation; and protein monoubiquitination. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

601 residues, UniProt reviewed canonical sequence.

>Q8NFY9|KBTBD8
     1  MAASADLSKS SPTPNGIPSS DPASDAMDPF HACSILKQLK TMYDEGQLTD IVVEVDHGKT
    61  FSCHRNVLAA ISPYFRSMFT SGLTESTQKE VRIVGVEAES MDLVLNYAYT SRVILTEANV
   121  QALFTAASIF QIPSIQDQCA KYMISHLDPQ NSIGVFIFAD HYGHQELGDR SKEYIRKKFL
   181  CVTKEQEFLQ LTKDQLISIL DSDDLNVDRE EHVYESIIRW FEHEQNEREV HLPEIFAKCI
   241  RFPLMEDTFI EKIPPQFAQA IAKSCVEKGP SNTNGCTQRL GMTASEMIIC FDAAHKHSGK
   301  KQTVPCLDIV TGRVFKLCKP PNDLREVGIL VSPDNDIYIA GGYRPSSSEV SIDHKAENDF
   361  WMYDHSTNRW LSKPSLLRAR IGCKLVYCCG KMYAIGGRVY EGDGRNSLKS VECYDSRENC
   421  WTTVCAMPVA MEFHNAVEYK EKIYVLQGEF FLFYEPQKDY WGFLTPMTVP RIQGLAAVYK
   481  DSIYYIAGTC GNHQRMFTVE AYDIELNKWT RKKDFPCDQS INPYLKLVLF QNKLHLFVRA
   541  TQVTVEEHVF RTSRKNSLYQ YDDIADQWMK VYETPDRLWD LGRHFECAVA KLYPQCLQKV
   601  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KBTBD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 19 nTPM
  • lymph node: 19 nTPM
  • bone marrow: 13 nTPM
  • testis: 7.3 nTPM
  • appendix: 6.5 nTPM
  • spleen: 5.4 nTPM

Single-cell type

  • b-cells: 34 nCPM
  • cdc: 28 nCPM
  • cardiomyocytes: 27 nCPM
  • monocytes: 27 nCPM
  • plasma cells: 21 nCPM
  • macrophages: 20 nCPM

Immune cell

  • naive B-cell: 6.8 nTPM
  • memory B-cell: 6.3 nTPM
  • intermediate monocyte: 3 nTPM
  • non-classical monocyte: 2.6 nTPM
  • myeloid DC: 2.4 nTPM
  • T-reg: 2.4 nTPM

Brain region

  • choroid plexus: 11 nTPM
  • cerebral cortex: 8.6 nTPM
  • basal ganglia: 6.3 nTPM
  • cerebellum: 5.6 nTPM
  • hippocampal formation: 4.9 nTPM
  • white matter: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
1.25
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KBTBD8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KBTBD8 as an antibody target. Whether an autoantibody or antibody against KBTBD8 could matter depends on whether native KBTBD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KBTBD8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KBTBD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KBTBD8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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