Seroatlas · Human Serome Atlas

ZBTB48

Zinc finger and BTB domain-containing protein 48

Also known as: HKR3, TZAP, ZBT48_HUMAN, ZNF855

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P10074
Gene: ZBTB48
Ensembl: ENSG00000204859
Chromosome: 1
Canonical length: 688 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables double-stranded telomeric DNA binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in positive regulation of DNA-templated transcription and telomere maintenance via telomere lengthening. Located in chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

688 residues, UniProt reviewed canonical sequence.

>P10074|ZBTB48
     1  MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF FQSLYGDGSG
    61  GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAR ELRVPEAVEL CQSFKPKTSV
   121  GQAAGGQSGL GPPASQNVNS HVKEPAGLEE EEVSRTLGLV PRDQEPRGSH SPQRPQLHSP
   181  AQSEGPSSLC GKLKQALKPC PLEDKKPEDC KVPPRPLEAE GAQLQGGSNE WEVVVQVEDD
   241  GDGDYMSEPE AVLTRRKSNV IRKPCAAEPA LSAGSLAAEP AENRKGTAVP VECPTCHKKF
   301  LSKYYLKVHN RKHTGEKPFE CPKCGKCYFR KENLLEHEAR NCMNRSEQVF TCSVCQETFR
   361  RRMELRVHMV SHTGEMPYKC SSCSQQFMQK KDLQSHMIKL HGAPKPHACP TCAKCFLSRT
   421  ELQLHEAFKH RGEKLFVCEE CGHRASSRNG LQMHIKAKHR NERPHVCEFC SHAFTQKANL
   481  NMHLRTHTGE KPFQCHLCGK TFRTQASLDK HNRTHTGERP FSCEFCEQRF TEKGPLLRHV
   541  ASRHQEGRPH FCQICGKTFK AVEQLRVHVR RHKGVRKFEC TECGYKFTRQ AHLRRHMEIH
   601  DRVENYNPRQ RKLRNLIIED EKMVVVALQP PAELEVGSAE VIVESLAQGG LASQLPGQRL
   661  CAEESFTGPG VLEPSLIITA AVPEDCDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB48 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

testis: 25 nTPM
liver: 21 nTPM
ovary: 16 nTPM
thymus: 16 nTPM
spleen: 15 nTPM
prostate: 15 nTPM

Single-cell type

late primary spermatocytes: 75 nCPM
early spermatids: 47 nCPM
oocytes: 41 nCPM
enterocytes: 33 nCPM
adrenal medulla cells: 32 nCPM
mast cells: 28 nCPM

Immune cell

eosinophil: 43 nTPM
basophil: 20 nTPM
neutrophil: 15 nTPM
myeloid DC: 12 nTPM
non-classical monocyte: 11 nTPM
classical monocyte: 11 nTPM

Brain region

choroid plexus: 18 nTPM
white matter: 16 nTPM
thalamus: 15 nTPM
cerebral cortex: 15 nTPM
midbrain: 15 nTPM
hypothalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB48 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EP300

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB48 as an antibody target. Whether an autoantibody or antibody against ZBTB48 could matter depends on whether native ZBTB48 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB48 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB48 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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