Seroatlas · Human Serome Atlas

SKP1

S-phase kinase-associated protein 1

Also known as: EMC19, MGC34403, OCP-II, OCP2, p19A, SKP1_HUMAN, SKP1A, TCEB1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P63208
Gene: SKP1
Ensembl: ENSG00000113558
Chromosome: 5
Canonical length: 163 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Primary cilium,Cytosol

OverviewNCBI Gene

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>P63208|SKP1
     1  MPSIKLQSSD GEIFEVDVEI AKQSVTIKTM LEDLGMDDEG DDDPVPLPNV NAAILKKVIQ
    61  WCTHHKDDPP PPEDDENKEK RTDDIPVWDQ EFLKVDQGTL FELILAANYL DIKGLLDVTC
   121  KTVANMIKGK TPEEIRKTFN IKNDFTEEEE AQVRKENQWC EEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SKP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 1,010 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 1,010 nTPM
blood vessel: 735 nTPM
spinal cord: 681 nTPM
midbrain: 678 nTPM
cerebral cortex: 640 nTPM
choroid plexus: 627 nTPM

Single-cell type

oocytes: 249 nCPM
parietal cells: 212 nCPM
syncytiotrophoblasts: 173 nCPM
epididymal efferent duct absorptive cells: 150 nCPM
fallopian tube ciliated cells: 149 nCPM
other brain neurons: 143 nCPM

Immune cell

total PBMC: 2,437 nTPM
basophil: 1,615 nTPM
eosinophil: 1,380 nTPM
naive CD4 T-cell: 1,377 nTPM
T-reg: 1,321 nTPM
memory CD4 T-cell: 1,166 nTPM

Brain region

cerebral cortex: 369 nTPM
choroid plexus: 344 nTPM
white matter: 339 nTPM
hypothalamus: 338 nTPM
pons: 323 nTPM
medulla oblongata: 322 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.37
gnomAD missense Z: 2.66
DepMap mean gene effect: -1.45
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

S-phase kinase-associated protein 1-like
SKP1/BTB/POZ domain superfamily
SKP1 component, POZ domain
Skp1 family, tetramerisation domain
SKP1 component, dimerisation
S-phase kinase-associated protein 1
SKP1-like, dimerisation domain superfamily
Skp1 family, dimerisation domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SKP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SKP1 as an antibody target. Whether an autoantibody or antibody against SKP1 could matter depends on whether native SKP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SKP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SKP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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