Seroatlas · Human Serome Atlas

ZBTB26

Zinc finger and BTB domain-containing protein 26

Also known as: ZBT26_HUMAN, ZNF481

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCK0
Gene: ZBTB26
Ensembl: ENSG00000171448
Chromosome: 9
Canonical length: 441 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables identical protein binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q9HCK0|ZBTB26
     1  MSERSDLLHF KFENYGDSML QKMNKLREEN KFCDVTVLID DIEVQGHKIV FAAGSPFLRD
    61  QFLLNDSREV KISILQSSEV GRQLLLSCYS GVLEFPEMEL VNYLTAASFL QMSHIVERCT
   121  QALWKFIKPK QPMDSKEGCE PQSASPQSKE QQGDARGSPK QDSPCIHPSE DSMDMEDSDI
   181  QIVKVESIGD VSEVRSKKDQ NQFISSEPTA LHSSEPQHSL INSTVENRVS EIEQNHLHNY
   241  ALSYTGSDNI IMASKDVFGP NIRGVDKGLQ WHHQCPKCTR VFRHLENYAN HLKMHKLFMC
   301  LLCGKTFTQK GNLHRHMRVH AGIKPFQCKI CGKTFSQKCS LQDHLNLHSG DKPHKCNYCD
   361  MVFAHKPVLR KHLKQLHGKN SFDNANERNV QDLTVDFDSF ACTTVTDSKG CQPQPDATQV
   421  LDAGKLAQAV LNLRNDSTCV N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

retina: 10 nTPM
testis: 9.2 nTPM
ovary: 8.2 nTPM
endometrium: 7.5 nTPM
parathyroid gland: 7.1 nTPM
thyroid gland: 6.6 nTPM

Single-cell type

late spermatids: 105 nCPM
sertoli cells: 43 nCPM
late primary spermatocytes: 34 nCPM
myonuclei: 34 nCPM
early spermatids: 31 nCPM
oligodendrocytes: 23 nCPM

Immune cell

basophil: 1.5 nTPM
intermediate monocyte: 1.4 nTPM
NK-cell: 1 nTPM
myeloid DC: 0.9 nTPM
eosinophil: 0.7 nTPM
naive B-cell: 0.7 nTPM

Brain region

white matter: 11 nTPM
cerebellum: 10 nTPM
basal ganglia: 8.5 nTPM
cerebral cortex: 8.2 nTPM
medulla oblongata: 8.1 nTPM
hypothalamus: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.14
gnomAD missense Z: 2.48
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB26 as an antibody target. Whether an autoantibody or antibody against ZBTB26 could matter depends on whether native ZBTB26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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