Seroatlas · Human Serome Atlas

ZBTB41

Zinc finger and BTB domain-containing protein 41

Also known as: DKFZp686C06120, FLJ36199, FRBZ1, ZBT41_HUMAN, ZNF924

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SVQ8
Gene: ZBTB41
Ensembl: ENSG00000177888
Chromosome: 1
Canonical length: 909 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

909 residues, UniProt reviewed canonical sequence.

>Q5SVQ8|ZBTB41
     1  MKKRRKVTSN LEKIHLGYHK DSSEGNVAVE CDQVTYTHSA GRPTPEALHC YQELPPSPDQ
    61  RKLLSSLQYN KNLLKYLNDD RQKQPSFCDL LIIVEGKEFS AHKVVVAVGS SYFHACLSKN
   121  PSTDVVTLDH VTHSVFQHLL EFLYTSEFFV YKYEIPLVLE AAKFLDIIDA VKLLNNENVA
   181  PFHSELTEKS SPEETLNELT GRLSNNHQCK FCSRHFCYKK SLENHLAKTH RSLLLGKKHG
   241  LKMLERSFSA RRSKRNRKCP VKFDDTSDDE QESGDGSDNL NQENFDKEKS DRNDSEDPGS
   301  EYNAEEDELE EEMSDEYSDI EEQSEKDHND AEEEPEAGDS VGNVHEGLTP VVIQNSNKKI
   361  LQCPKCDKTF DRIGKYESHT RVHTGEKPFE CDICHQRYST KSNLTVHRKK HSNETEFHKK
   421  EHKCPYCNKL HASKKTLAKH VKRFHPENAQ EFISIKKTKS ESWKCDICKK SFTRRPHLEE
   481  HMILHSQDKP FKCTYCEEHF KSRFARLKHQ EKFHLGPFPC DICGRQFNDT GNLKRHIECT
   541  HGGKRKWTCF ICGKSVRERT TLKEHLRIHS GEKPHLCSIC GQSFRHGSSY RLHLRVHHDD
   601  KRYECDECGK TFIRHDHLTK HKKIHSGEKA HQCEECGKCF GRRDHLTVHY KSVHLGEKVW
   661  QKYKATFHQC DVCKKIFKGK SSLEMHFRTH SGEKPYKCQI CNQSFRIKKT LTKHLVIHSD
   721  ARPFNCQHCN ATFKRKDKLK YHIDHVHEIK SPDDPLSTSE EKLVSLPVEY SSDDKIFQTE
   781  TKQYMDQPKV YQSEAKTMLQ NVSAEVCVPV TLVPVQMPDT PSDLVRHTTT LPPSSHEILS
   841  PQPQSTDYPR AADLAFLEKY TLTPQPANIV HPVRPEQMLD PREQSYLGTL LGLDSTTGVQ
   901  NISTNEHHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 8.6 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 8.6 nTPM
thyroid gland: 7 nTPM
breast: 6.5 nTPM
ovary: 6.5 nTPM
retina: 6.5 nTPM
cerebral cortex: 5.5 nTPM

Single-cell type

corticotrophs: 92 nCPM
ependymal cells: 67 nCPM
lactotrophs: 62 nCPM
somatotrophs: 60 nCPM
pancreatic islet cells: 53 nCPM
oligodendrocytes: 48 nCPM

Immune cell

MAIT T-cell: 0.4 nTPM
memory B-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
NK-cell: 0.4 nTPM
basophil: 0.3 nTPM

Brain region

white matter: 18 nTPM
cerebellum: 18 nTPM
midbrain: 18 nTPM
spinal cord: 17 nTPM
hypothalamus: 17 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.22
gnomAD missense Z: 2.41
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB41 as an antibody target. Whether an autoantibody or antibody against ZBTB41 could matter depends on whether native ZBTB41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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