Seroatlas · Human Serome Atlas

KCNRG

Potassium channel regulatory protein

Also known as: KCNRG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5I3
Gene: KCNRG
Ensembl: ENSG00000198553
Chromosome: 13
Canonical length: 272 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles,Centriolar satellite,Basal body
Quaternary structure: Homooligomer

OverviewNCBI Gene

This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>Q8N5I3|KCNRG
     1  MSSQELVTLN VGGKIFTTRF STIKQFPASR LARMLDGRDQ EFKMVGGQIF VDRDGDLFSF
    61  ILDFLRTHQL LLPTEFSDYL RLQREALFYE LRSLVDLLNP YLLQPRPALV EVHFLSRNTQ
   121  AFFRVFGSCS KTIEMLTGRI TVFTEQPSAP TWNGNFFPPQ MTLLPLPPQR PSYHDLVFQC
   181  GSDSTTDNQT GVRYVSIKPD NRKLANGTNV LGLLIDTLLK EGFHLVSTRT VSSEDKTECY
   241  SFERIKSPEV LITNETPKPE TIIIPEQSQI KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNRG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 34 nTPM
lung: 2.9 nTPM
testis: 2.1 nTPM
bone marrow: 1.8 nTPM
endometrium: 1.2 nTPM
cervix: 1.1 nTPM

Single-cell type

fallopian tube ciliated cells: 111 nCPM
respiratory ciliated cells: 100 nCPM
endometrial ciliated cells: 52 nCPM
epididymal efferent duct ciliated cells: 31 nCPM
late primary spermatocytes: 29 nCPM
late spermatids: 20 nCPM

Immune cell

neutrophil: 1.1 nTPM
basophil: 0.9 nTPM
naive B-cell: 0.6 nTPM
memory B-cell: 0.4 nTPM
NK-cell: 0.4 nTPM
T-reg: 0.4 nTPM

Brain region

white matter: 12 nTPM
cerebellum: 12 nTPM
basal ganglia: 10 nTPM
medulla oblongata: 9.8 nTPM
cerebral cortex: 9.5 nTPM
thalamus: 8.4 nTPM

ReferencesPubMed · IEDB

Publications for KCNRG from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

2 publications

Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen.
2009 · Proc Natl Acad Sci U S A · RCR 1.8 · 75 citations
Autoimmune polyendocrine syndrome type 1: Utility of KCNRG autoantibodies as a marker of active pulmonary disease and successful treatment with rituximab.
2012 · Pediatr Pulmonol · RCR 0.8 · 29 citations

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

endoplasmic reticulum

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Endoplasmic reticulum

InteractionsUniProt · HPA

Protein binding partners of KCNRG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

KCNA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNRG as an antibody target. Whether an autoantibody or antibody against KCNRG could matter depends on whether native KCNRG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNRG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCNRG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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