Seroatlas · Human Serome Atlas

GMCL2

Germ cell-less protein-like 2

Also known as: GCL, GMCL1L, GMCL1P1, GMCL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEA9
Gene: GMCL2
Ensembl: ENSG00000244234
Chromosome: 5
Canonical length: 526 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This locus shares a high degree of identity with the multi-exon germ cell-less gene on chromosome 2. Despite its single-exon nature, this chromosome 5 locus contains an open reading frame that could putatively encode a full-length germ cell-less related protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

526 residues, UniProt reviewed canonical sequence.

>Q8NEA9|GMCL2
     1  MGSSSSRVLG QPRRALAQQE QGARARGSAR RPDTGDDAAS YGFCYCPGSH KRKRSSGACR
    61  YCDPDSHREE HEEEGDKQQP LLNTPARKKL RSTSKYIYQT LFLNGENSDI KICALGEEWR
   121  LHKIYLCQSG YFSSMFSGSW KESSMNIIEL EIPDQNIDVD ALQVAFGSLY RDDVLIKPSR
   181  VVAILAAACM LQLDGLIQQC GETMKETINV KTVCGYYTSV EIYGLDSVKK KCLEWLLNNL
   241  MTHQNVKLFK ELGINVMKQL IGSSNLFVMQ VEMDVYTTLK KWMFLQLVPS WNGSLKQLLT
   301  ETDVWFSKQR KDFEGMAFLE TEPGKPFVSV FRHLRLQYII SDLASARIIE QDGIVPSEWL
   361  SSVYKQQWFA MLRAEQDREV GPQEINKEDL EGNSMRCGRK LAKDGEYYWC WTGFNFGFDL
   421  LVIYTNGYII FKRNTLNQPR SGSVSLRPRR SIAFRLRLAS FDSSGKLVCS RTTGYQILIL
   481  KKDQEQVVMN LDSRFLTFPL YICCNFLYIS PEKGIENNRH PENPEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GMCL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

testis: 18 nTPM
parathyroid gland: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late primary spermatocytes: 184 nCPM
early primary spermatocytes: 27 nCPM
early spermatids: 15 nCPM
late spermatids: 7.7 nCPM
peritubular myoid cells: 0.9 nCPM
leydig cells: 0.5 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.2 nTPM
cerebellum: 0.1 nTPM
hypothalamus: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM

OntologyGO

Biological processes

Molecular functions

cullin family protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GMCL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CUL3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GMCL2 as an antibody target. Whether an autoantibody or antibody against GMCL2 could matter depends on whether native GMCL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GMCL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GMCL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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