Seroatlas · Human Serome Atlas

KCTD10

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

Also known as: BACD3_HUMAN, BTBD28, MSTP028

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3F6
Gene: KCTD10
Ensembl: ENSG00000110906
Chromosome: 12
Canonical length: 313 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homotetramer

OverviewNCBI Gene

The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q9H3F6|KCTD10
     1  MEEMSGESVV SSAVPAAATR TTSFKGTSPS SKYVKLNVGG ALYYTTMQTL TKQDTMLKAM
    61  FSGRMEVLTD SEGWILIDRC GKHFGTILNY LRDGAVPLPE SRREIEELLA EAKYYLVQGL
   121  VEECQAALQN KDTYEPFCKV PVITSSKEEQ KLIATSNKPA VKLLYNRSNN KYSYTSNSDD
   181  NMLKNIELFD KLSLRFNGRV LFIKDVIGDE ICCWSFYGQG RKIAEVCCTS IVYATEKKQT
   241  KVEFPEARIY EETLNILLYE AQDGRGPDNA LLEATGGAAG RSHHLDEDEE RERIERVRRI
   301  HIKRPDDRAH LHQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 103 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 103 nTPM
smooth muscle: 53 nTPM
thyroid gland: 44 nTPM
colon: 43 nTPM
choroid plexus: 42 nTPM
seminal vesicle: 42 nTPM

Single-cell type

platelets: 95 nCPM
esophageal apical cells: 88 nCPM
retinal pigment epithelial cells: 60 nCPM
vascular smooth muscle cells: 47 nCPM
smooth muscle cells: 46 nCPM
hepatic stellate cells: 45 nCPM

Immune cell

NK-cell: 25 nTPM
non-classical monocyte: 17 nTPM
total PBMC: 15 nTPM
intermediate monocyte: 14 nTPM
gdT-cell: 14 nTPM
myeloid DC: 12 nTPM

Brain region

choroid plexus: 50 nTPM
hypothalamus: 48 nTPM
pons: 39 nTPM
midbrain: 32 nTPM
thalamus: 27 nTPM
medulla oblongata: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.86
gnomAD missense Z: 2.35
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCTD10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD10 as an antibody target. Whether an autoantibody or antibody against KCTD10 could matter depends on whether native KCTD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCTD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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