Seroatlas · Human Serome Atlas

KBTBD6

Kelch repeat and BTB domain-containing protein 6

Also known as: DKFZp547E1912, KBTB6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86V97
Gene: KBTBD6
Ensembl: ENSG00000165572
Chromosome: 13
Canonical length: 674 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and regulation of Rac protein signal transduction. Located in cytoplasm and nucleus. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>Q86V97|KBTBD6
     1  MQSREDAPRS RRLASPRGGK RPKKIHKPTV SAFFTGPEEL KDTAHSAALL AQLKSFYDAR
    61  LLCDVTIEVV TPGSGPGTGR LFPCNRNVLA AACPYFKSMF TGGMYESQQA SVTMHDVDAE
   121  SFEVLVDYCY TGRVSLSEAN VERLYAASDM LQLEYVREAC ASFLARRLDL TNCTAILKFA
   181  DAFGHRKLRS QAQSYIAQNF KQLSHMGSIR EETLADLTLA QLLAVLRLDS LDVESEQTVC
   241  HVAVQWLEAA PKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ
   301  MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG HPRDPFLCCD
   361  PYSGDLYKVP SPLTCLAHTR TVTTLAVCIS PDHDIYLAAQ PRTDLWVYKP AQNSWQQLAD
   421  RLLCREGMDV AYLNGYIYIL GGRDPITGVK LKEVECYNVK RNQWALVAPL PHSFLSFDLM
   481  VIRDYLYALN SKRMFCYDPS HNMWLKCVSL KRNDFQEACV FNEEIYCICD IPVMKVYNPV
   541  RAEWRQMNNI PLVSETNNYR IIKHGQKLLL ITSRTPQWKK NRVTVYEYDI RGDQWINIGT
   601  TLGLLQFDSN FFCLSARVYP SCLEPGQSFL TEEEEIPSES STEWDLGGFS EPDSESGSSS
   661  SLSDDDFWVR VAPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KBTBD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 14 nTPM
cerebellum: 13 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 10 nTPM
amygdala: 8.8 nTPM
hippocampal formation: 8.6 nTPM

Single-cell type

neutrophil progenitors: 74 nCPM
other brain neurons: 33 nCPM
adrenal medulla cells: 32 nCPM
corticotrophs: 32 nCPM
neutrophils: 30 nCPM
brain inhibitory neurons: 23 nCPM

Immune cell

basophil: 3.6 nTPM
naive CD8 T-cell: 3.4 nTPM
naive CD4 T-cell: 3.2 nTPM
non-classical monocyte: 2.9 nTPM
memory CD4 T-cell: 2.8 nTPM
memory CD8 T-cell: 2.2 nTPM

Brain region

hypothalamus: 33 nTPM
basal ganglia: 24 nTPM
cerebral cortex: 23 nTPM
midbrain: 22 nTPM
pons: 22 nTPM
cerebellum: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
gnomAD missense Z: 2.58
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KBTBD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KBTBD6 as an antibody target. Whether an autoantibody or antibody against KBTBD6 could matter depends on whether native KBTBD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KBTBD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KBTBD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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