Seroatlas · Human Serome Atlas

KCTD13

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

Also known as: BACD1_HUMAN, FKSG86, PDIP1, POLDIP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WZ19
Gene
KCTD13
Ensembl
ENSG00000174943
Chromosome
16
Canonical length
329 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies
Quaternary structure
Homotetramer

OverviewNCBI Gene

Enables identical protein binding activity and small GTPase binding activity. Contributes to ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of Rho protein signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; and stress fiber assembly. Located in nuclear body. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q8WZ19|KCTD13
     1  MSAEASGPAA AAAPSLEAPK PSGLEPGPAA YGLKPLTPNS KYVKLNVGGS LHYTTLRTLT
    61  GQDTMLKAMF SGRVEVLTDA GGWVLIDRSG RHFGTILNYL RDGSVPLPES TRELGELLGE
   121  ARYYLVQGLI EDCQLALQQK RETLSPLCLI PMVTSPREEQ QLLASTSKPV VKLLHNRSNN
   181  KYSYTSTSDD NLLKNIELFD KLALRFHGRL LFLKDVLGDE ICCWSFYGQG RKIAEVCCTS
   241  IVYATEKKQT KVEFPEARIF EETLNILIYE TPRGPDPALL EATGGAAGAG GAGRGEDEEN
   301  REHRVRRIHV RRHITHDERP HGQQIVFKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 65 nTPM
  • basal ganglia: 63 nTPM
  • testis: 62 nTPM
  • amygdala: 49 nTPM
  • cerebral cortex: 48 nTPM
  • hypothalamus: 28 nTPM

Single-cell type

  • epicardial cells: 271 nCPM
  • sertoli cells: 134 nCPM
  • undifferentiated spermatogonia: 44 nCPM
  • astrocytes: 36 nCPM
  • oligodendrocytes: 35 nCPM
  • proximal tubule cells: 33 nCPM

Immune cell

  • neutrophil: 11 nTPM
  • eosinophil: 8.1 nTPM
  • basophil: 7.2 nTPM
  • memory CD4 T-cell: 5.5 nTPM
  • memory CD8 T-cell: 5.1 nTPM
  • naive CD4 T-cell: 5 nTPM

Brain region

  • hippocampal formation: 61 nTPM
  • cerebral cortex: 61 nTPM
  • basal ganglia: 44 nTPM
  • white matter: 43 nTPM
  • amygdala: 41 nTPM
  • hypothalamus: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
1.92
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCTD13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD13 as an antibody target. Whether an autoantibody or antibody against KCTD13 could matter depends on whether native KCTD13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCTD13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCTD13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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