Seroatlas · Human Serome Atlas

ZBTB22

Zinc finger and BTB domain-containing protein 22

Also known as: BING1, fru, fruitless, ZBT22_HUMAN, ZBTB22A, ZNF297, ZNF297A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15209
Gene: ZBTB22
Ensembl: ENSG00000236104
Chromosome: 6
Canonical length: 634 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

634 residues, UniProt reviewed canonical sequence.

>O15209|ZBTB22
     1  MEPSPLSPSG AALPLPLSLA PPPLPLPAAA VVHVSFPEVT SALLESLNQQ RLQGQLCDVS
    61  IRVQGREFRA HRAVLAASSP YFHDQVLLKG MTSISLPSVM DPGAFETVLA SAYTGRLSMA
   121  AADIVNFLTV GSVLQMWHIV DKCTELLREG RASATTTITT AAATSVTVPG AGVPSGSGGT
   181  VAPATMGSAR SHASSRASEN QSPSSSNYFS PRESTDFSSS SQEAFAASAV GSGERRGGGP
   241  VFPAPVVGSG GATSGKLLLE ADELCDDGGD GRGAVVPGAG LRRPTYTPPS IMPQKHWVYV
   301  KRGGNCPAPT PLVPQDPDLE EEEEEEDLVL TCEDDEDEEL GGSSRVPVGG GPEATLSISD
   361  VRTLSEPPDK GEEQVNFCES SNDFGPYEGG GPVAGLDDSG GPTPSSYAPS HPPRPLLPLD
   421  MQGNQILVFP SSSSSSSSQA PGQPPGNQAE HGAVTVGGTS VGSLGVPGSV GGVPGGTGSG
   481  DGNKIFLCHC GKAFSHKSMR DRHVNMHLNL RPFDCPVCNK KFKMKHHLTE HMKTHTGLKP
   541  YECGVCAKKF MWRDSFMRHR GHCERRHRLG GVGAVPGPGT PTGPSLPSKR ESPGVGGGSG
   601  DEASAATPPS SRRVWSPPRV HKVEMGFGGG GGAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

skin: 18 nTPM
cervix: 15 nTPM
endometrium: 15 nTPM
adrenal gland: 14 nTPM
blood vessel: 14 nTPM
cerebral cortex: 14 nTPM

Single-cell type

ependymal cells: 9.5 nCPM
bergmann glia: 5.4 nCPM
papillary tip epithelial cells: 4.2 nCPM
microglia: 3.8 nCPM
other brain neurons: 3.8 nCPM
oligodendrocyte progenitor cells: 3.6 nCPM

Immune cell

basophil: 0.8 nTPM
eosinophil: 0.8 nTPM
naive CD4 T-cell: 0.7 nTPM
memory B-cell: 0.5 nTPM
memory CD4 T-cell: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM

Brain region

cerebral cortex: 6.2 nTPM
medulla oblongata: 4.8 nTPM
spinal cord: 3.9 nTPM
midbrain: 3.6 nTPM
pons: 3.6 nTPM
white matter: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.22
gnomAD missense Z: 1.86
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB22 as an antibody target. Whether an autoantibody or antibody against ZBTB22 could matter depends on whether native ZBTB22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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