ZBTB5
Zinc finger and BTB domain-containing protein 5
Also known as: KIAA0354, ZBTB5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O15062
- Gene
- ZBTB5
- Ensembl
- ENSG00000168795
- Chromosome
- 9
- Canonical length
- 677 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Nuclear bodies,Golgi apparatus
OverviewNCBI Gene
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
677 residues, UniProt reviewed canonical sequence.
>O15062|ZBTB5
1 MDFPGHFEQI FQQLNYQRLH GQLCDCVIVV GNRHFKAHRS VLAACSTHFR ALFSVAEGDQ
61 TMNMIQLDSE VVTAEAFAAL IDMMYTSTLM LGESNVMDVL LAASHLHLNS VVKACKHYLT
121 TRTLPMSPPS ERVQEQSARM QRSFMLQQLG LSIVSSALNS SQNGEEQPAP MSSSMRSNLD
181 QRTPFPMRRL HKRKQSAEER ARQRLRPSID ESAISDVTPE NGPSGVHSRE EFFSPDSLKI
241 VDNPKADGMT DNQEDSAIMF DQSFGTQEDA QVPSQSDNSA GNMAQLSMAS RATQVETSFD
301 QEAAPEKSSF QCENPEVGLG EKEHMRVVVK SEPLSSPEPQ DEVSDVTSQA EGSESVEVEG
361 VVVSAEKIDL SPESSDRSFS DPQSSTDRVG DIHILEVTNN LEHKSTFSIS NFLNKSRGNN
421 FTANQNNDDN IPNTTSDCRL ESEAPYLLSP EAGPAGGPSS APGSHVENPF SEPADSHFVR
481 PMQEVMGLPC VQTSGYQGGE QFGMDFSRSG LGLHSSFSRV MIGSPRGGAS NFPYYRRIAP
541 KMPVVTSVRS SQIPENSTSS QLMMNGATSS FENGHPSQPG PPQLTRASAD VLSKCKKALS
601 EHNVLVVEGA RKYACKICCK TFLTLTDCKK HIRVHTGEKP YACLKCGKRF SQSSHLYKHS
661 KTTCLRWQSS NLPSTLLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZBTB5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 17 nTPM
- bone marrow: 13 nTPM
- liver: 12 nTPM
- tonsil: 11 nTPM
- skin: 11 nTPM
- thyroid gland: 9.6 nTPM
Single-cell type
- esophageal apical cells: 69 nCPM
- epididymal principal cells: 52 nCPM
- ocular epithelial cells: 43 nCPM
- thymic myoid cells: 41 nCPM
- suprabasal keratinocytes: 40 nCPM
- epididymal basal cells: 38 nCPM
Immune cell
- memory B-cell: 0.9 nTPM
- naive CD8 T-cell: 0.9 nTPM
- myeloid DC: 0.8 nTPM
- naive CD4 T-cell: 0.8 nTPM
- MAIT T-cell: 0.7 nTPM
- naive B-cell: 0.7 nTPM
Brain region
- white matter: 15 nTPM
- cerebellum: 12 nTPM
- medulla oblongata: 12 nTPM
- basal ganglia: 11 nTPM
- cerebral cortex: 11 nTPM
- midbrain: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.48
- gnomAD pLI
- 0.62
- gnomAD missense Z
- 1.23
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of transcription by RNA polymerase II
- regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZBTB5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZBTB5 as an antibody target. Whether an autoantibody or antibody against ZBTB5 could matter depends on whether native ZBTB5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZBTB5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZBTB5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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