Seroatlas · Human Serome Atlas

KCNG2

Voltage-gated potassium channel regulatory subunit KCNG2

Also known as: KCNF2, KCNG2_HUMAN, Kv6.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJ96
Gene
KCNG2
Ensembl
ENSG00000178342
Chromosome
18
Canonical length
466 aa
Protein class
Predicted membrane proteins, Voltage-gated ion channels

OverviewNCBI Gene

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>Q9UJ96|KCNG2
     1  MEPWPCSPGG GGGTRARHVI INVGGCRVRL AWAALARCPL ARLERLRACR GHDDLLRVCD
    61  DYDVSRDEFF FDRSPCAFRA IVALLRAGKL RLLRGPCALA FRDELAYWGI DEARLERCCL
   121  RRLRRREEEA AEARAGPTER GAQGSPARAL GPRGRLQRGR RRLRDVVDNP HSGLAGKLFA
   181  CVSVSFVAVT AVGLCLSTMP DIRAEEERGE CSPKCRSLFV LETVCVAWFS FEFLLRSLQA
   241  ESKCAFLRAP LNIIDILALL PFYVSLLLGL AAGPGGTKLL ERAGLVLRLL RALRVLYVMR
   301  LARHSLGLRS LGLTMRRCAR EFGLLLLFLC VAMALFAPLV HLAERELGAR RDFSSVPASY
   361  WWAVISMTTV GYGDMVPRSL PGQVVALSSI LSGILLMAFP VTSIFHTFSR SYSELKEQQQ
   421  RAASPEPALQ EDSTHSATAT EDSSQGPDSA GLADDSADAL WVRAGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
2.5 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 2.5 nTPM
  • cerebral cortex: 1.4 nTPM
  • basal ganglia: 1.1 nTPM
  • amygdala: 0.7 nTPM
  • testis: 0.6 nTPM
  • hypothalamus: 0.4 nTPM

Single-cell type

  • retinal horizontal cells: 307 nCPM
  • epicardial cells: 173 nCPM
  • pdcs: 121 nCPM
  • neutrophils: 120 nCPM
  • oocytes: 69 nCPM
  • thymocytes: 64 nCPM

Immune cell

  • plasmacytoid DC: 0.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hippocampal formation: 8.7 nTPM
  • cerebral cortex: 7.9 nTPM
  • hypothalamus: 5.2 nTPM
  • midbrain: 4.8 nTPM
  • basal ganglia: 4.3 nTPM
  • spinal cord: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.6
gnomAD missense Z
1.75
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNG2 as an antibody target. Whether an autoantibody or antibody against KCNG2 could matter depends on whether native KCNG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNG2 is annotated at the cell surface, where native KCNG2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNG2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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