Seroatlas · Human Serome Atlas

ZBTB8B

Zinc finger and BTB domain-containing protein 8B

Also known as: DKFZp547H154, RP1-27O5.1, ZBT8B_HUMAN, ZNF916B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NAP8
Gene: ZBTB8B
Ensembl: ENSG00000273274
Chromosome: 1
Canonical length: 495 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>Q8NAP8|ZBTB8B
     1  MEMQSYYAKL LGELNEQRKR DFFCDCSIIV EGRIFKAHRN ILFANSGYFR ALLIHYIQDS
    61  GRHSTASLDI VTSDAFSIIL DFLYSGKLDL CGENVIEVMS AASYLQMNDV VNFCKTYIRS
   121  SLDICRKMEK EAAVAAAVAA AAAAAAAAAA AAAHQVDSES PSSGREGTSC GTKSLVSSPA
   181  EGEKSVECLR ESPCGDCGDC HPLELVVRDS LGGGSADSNL STPPKRIEPK VEFDADEVEV
   241  DVGEQLQQYA APLNLAHVEE ALPSGQAVDL AYSNYHVKQF LEALLRNSAA PSKDDADHHF
   301  SRSLEGRPEG AGVAMSSMMD VQADWYGEDS GDVLVVPIKL HKCPFCPYTA KQKGILKRHI
   361  RSHTGERPYP CETCGKRFTR QEHLRSHALS VHRSNRPIIC KGCRRTFTSH LSQGLRRFGL
   421  CDSCTCVTDT PDDDDDLMPI NLSLVEASSE SQEKSDTDND WPIYVESGEE NDPAGDDSDD
   481  KPQIQPNLSD RETLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

hypothalamus: 0.9 nTPM
amygdala: 0.7 nTPM
pituitary gland: 0.6 nTPM
cerebral cortex: 0.5 nTPM
midbrain: 0.5 nTPM
retina: 0.5 nTPM

Single-cell type

oligodendrocyte progenitor cells: 0.3 nCPM
gonadotrophs: 0.1 nCPM
other brain neurons: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0.8 nTPM
neutrophil: 0.5 nTPM
naive B-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM

Brain region

hypothalamus: 7.1 nTPM
midbrain: 7 nTPM
basal ganglia: 6.3 nTPM
medulla oblongata: 5.7 nTPM
amygdala: 5.4 nTPM
pons: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 2.62
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB8B as an antibody target. Whether an autoantibody or antibody against ZBTB8B could matter depends on whether native ZBTB8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB8B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...