LGALS3BP

Protein identityUniProt · HPA

UniProt accession

Q08380

Gene

LGALS3BP

Ensembl

ENSG00000108679

Chromosome

17

Canonical length

585 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted secreted proteins

Secretome location

Secreted to blood

Quaternary structure

Homodimer

OverviewNCBI Gene

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q08380|LGALS3BP
     1  MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD NLWDLTDASV
    61  VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL ADCKSLGWLK SNCRHERDAG
   121  VVCTNETRST HTLDLSRELS EALGQIFDSQ RGCDLSISVN VQGEDALGFC GHTVILTANL
   181  EAQALWKEPG SNVTMSVDAE CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ
   241  GYCASLFAIL LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP
   301  TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM MLPEELFELQ
   361  FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT EDTYKPRIYT SPTWSAFVTD
   421  SSWSARKSQL VYQSRRGPLV KYSSDYFQAP SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL
   481  VYLPTIQSCW NYGFSCSSDE LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW
   541  KAAIPSALDT NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LGALS3BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.29

Highest tissue expression

470 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LGALS3BP.

Disease | ImmuneIEDB

Conditions an epitope on LGALS3BP was assayed in.

• colon cancer T cell
• skin melanoma T cell

ReferencesPubMed · IEDB

Publications for LGALS3BP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.43

gnomAD pLI

0

gnomAD missense Z

0.08

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• cellular defense response
• signal transduction

Molecular functions

• scavenger receptor activity

Cellular components

• blood microparticle
• extracellular exosome
• extracellular matrix
• extracellular region
• extracellular space
• membrane
• platelet dense granule lumen

Protein domainsUniProt · Pfam · InterPro

• BTB/POZ domain
• SRCR domain
• SKP1/BTB/POZ domain superfamily
• BTB/Kelch-associated
• SRCR-like domain superfamily
• BTB/POZ domain-containing protein and Galectin-3-binding
• Scavenger receptor cysteine-rich domain
• BTB And C-terminal Kelch

KeywordsUniProt

• Cell adhesion
• Disulfide bond
• Extracellular matrix
• Glycoprotein
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of LGALS3BP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDK5RAP2
• NID1
• LGALS3
• FN1
• BCL2L14
• CANX
• FBXO6
• MX1
• SAMHD1
• TNFRSF10A
• VAMP5