Seroatlas · Human Serome Atlas

ZBTB6

Zinc finger and BTB domain-containing protein 6

Also known as: ZBTB6_HUMAN, ZID, ZNF482

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15916
Gene: ZBTB6
Ensembl: ENSG00000186130
Chromosome: 9
Canonical length: 424 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>Q15916|ZBTB6
     1  MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI LAACSTFMRD
    61  QFLLTQSKHV RITILQSAEV GRKLLLSCYT GALEVKRKEL LKYLTAASYL QMVHIVEKCT
   121  EALSKYLEID LSMKNNNQHT DLCQSSDPDV KNEDENSDKD CEIIEISEDS PVNIDFHVKE
   181  EESNALQSTV ESLTSERKEM KSPELSTVDI GFKDNEICIL HVESISTAGV ENGQFSQPCT
   241  SSKASMYFSE TQHSLINSTV ESRVAEVPGN QDQGLFCENT EGSYGTVSEI QNLEEGYSLR
   301  HQCPRCPRGF LHVENYLRHL KMHKLFLCLQ CGKTFTQKKN LNRHIRGHMG IRPFQCTVCL
   361  KTFTAKSTLQ DHLNIHSGDR PYKCHCCDMD FKHKSALKKH LTSVHGRSSG EKLSRPDLKR
   421  QSLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

lymph node: 9.1 nTPM
tonsil: 8.6 nTPM
thyroid gland: 7 nTPM
thymus: 6.8 nTPM
retina: 6.7 nTPM
appendix: 6.6 nTPM

Single-cell type

cone photoreceptor cells: 17 nCPM
rod photoreceptor cells: 15 nCPM
corticotrophs: 14 nCPM
medullary thymic epithelial cells: 14 nCPM
schwann cells: 14 nCPM
early spermatids: 12 nCPM

Immune cell

basophil: 11 nTPM
non-classical monocyte: 3 nTPM
NK-cell: 2.5 nTPM
naive CD4 T-cell: 2.4 nTPM
eosinophil: 2.3 nTPM
naive CD8 T-cell: 2.2 nTPM

Brain region

cerebellum: 10 nTPM
white matter: 10 nTPM
spinal cord: 8.1 nTPM
basal ganglia: 7.4 nTPM
medulla oblongata: 7.4 nTPM
cerebral cortex: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.14
gnomAD missense Z: 1.72
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB6 as an antibody target. Whether an autoantibody or antibody against ZBTB6 could matter depends on whether native ZBTB6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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